Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease.
Publication
, Journal Article
Luo, AK; Jefferson, BK; Garcia, MJ; Ginsburg, GS; Topol, EJ
Published in: J Med Genet
March 2007
Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology, which now allows genotyping of hundreds of thousands of single-nucleotide polymorphisms in each individual, there remains a pattern of inconsistency in the studies performed to date, in part owing to the difficulties in defining cases and controls. In this paper, salient issues to facilitate research in this important field are reviewed.
Duke Scholars
Published In
J Med Genet
DOI
EISSN
1468-6244
Publication Date
March 2007
Volume
44
Issue
3
Start / End Page
161 / 165
Location
England
Related Subject Headings
- Tomography, X-Ray Computed
- Polymorphism, Single Nucleotide
- Phenotype
- Patient Selection
- Myocardial Infarction
- Middle Aged
- Male
- Humans
- Genetics & Heredity
- Genetic Predisposition to Disease
Citation
APA
Chicago
ICMJE
MLA
NLM
Luo, A. K., Jefferson, B. K., Garcia, M. J., Ginsburg, G. S., & Topol, E. J. (2007). Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease. J Med Genet, 44(3), 161–165. https://doi.org/10.1136/jmg.2006.045732
Luo, Albert K., Brian K. Jefferson, Mario J. Garcia, Geoffrey S. Ginsburg, and Eric J. Topol. “Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease.” J Med Genet 44, no. 3 (March 2007): 161–65. https://doi.org/10.1136/jmg.2006.045732.
Luo AK, Jefferson BK, Garcia MJ, Ginsburg GS, Topol EJ. Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease. J Med Genet. 2007 Mar;44(3):161–5.
Luo, Albert K., et al. “Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease.” J Med Genet, vol. 44, no. 3, Mar. 2007, pp. 161–65. Pubmed, doi:10.1136/jmg.2006.045732.
Luo AK, Jefferson BK, Garcia MJ, Ginsburg GS, Topol EJ. Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease. J Med Genet. 2007 Mar;44(3):161–165.
Published In
J Med Genet
DOI
EISSN
1468-6244
Publication Date
March 2007
Volume
44
Issue
3
Start / End Page
161 / 165
Location
England
Related Subject Headings
- Tomography, X-Ray Computed
- Polymorphism, Single Nucleotide
- Phenotype
- Patient Selection
- Myocardial Infarction
- Middle Aged
- Male
- Humans
- Genetics & Heredity
- Genetic Predisposition to Disease