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Actions of steroids in mitochondria.

Publication ,  Journal Article
Gavrilova-Jordan, LP; Price, TM
Published in: Semin Reprod Med
May 2007

Investigations of indirect and direct actions of steroids on the mitochondria are relatively new areas of research. In this review we provide brief background information regarding mitochondrial structure and function and then focus upon interactions of glucocorticoid, estrogen, androgen, and progesterone receptors with mitochondria. We evaluate the current evidence for steroid receptor localization in the mitochondria based on techniques of Western blot analysis, immunocytochemistry, electron microscopy, and mass spectrometry. Steroid receptor-dependent interactions with mitochondria may include transcriptional regulation of nuclear DNA-encoded mitochondrial proteins, transcriptional regulation of mitochondrial DNA-encoded proteins, or indirect effects on mitochondria due to interactions with cytoplasmic signaling peptides and non-genomic control of cation fluxes. These interactions may play a role in mitochondrial-dependent processes of oxidative phosphorylation and apoptosis. Physiological examples of these interactions are discussed.

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Published In

Semin Reprod Med

DOI

ISSN

1526-8004

Publication Date

May 2007

Volume

25

Issue

3

Start / End Page

154 / 164

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • Receptors, Steroid
  • Receptors, Progesterone
  • Receptors, Glucocorticoid
  • Receptors, Estrogen
  • Receptors, Androgen
  • Progesterone
  • Oxidative Phosphorylation
  • Obstetrics & Reproductive Medicine
 

Citation

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Gavrilova-Jordan, L. P., & Price, T. M. (2007). Actions of steroids in mitochondria. Semin Reprod Med, 25(3), 154–164. https://doi.org/10.1055/s-2007-973428
Gavrilova-Jordan, Larisa P., and Thomas M. Price. “Actions of steroids in mitochondria.Semin Reprod Med 25, no. 3 (May 2007): 154–64. https://doi.org/10.1055/s-2007-973428.
Gavrilova-Jordan LP, Price TM. Actions of steroids in mitochondria. Semin Reprod Med. 2007 May;25(3):154–64.
Gavrilova-Jordan, Larisa P., and Thomas M. Price. “Actions of steroids in mitochondria.Semin Reprod Med, vol. 25, no. 3, May 2007, pp. 154–64. Pubmed, doi:10.1055/s-2007-973428.
Gavrilova-Jordan LP, Price TM. Actions of steroids in mitochondria. Semin Reprod Med. 2007 May;25(3):154–164.
Journal cover image

Published In

Semin Reprod Med

DOI

ISSN

1526-8004

Publication Date

May 2007

Volume

25

Issue

3

Start / End Page

154 / 164

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • Receptors, Steroid
  • Receptors, Progesterone
  • Receptors, Glucocorticoid
  • Receptors, Estrogen
  • Receptors, Androgen
  • Progesterone
  • Oxidative Phosphorylation
  • Obstetrics & Reproductive Medicine