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Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis.

Publication ,  Journal Article
Weinberg, JB; Hasstedt, SJ; Skolnick, MH; Kimberling, WJ; Baty, B
Published in: Am J Med Genet
1980
Published version (DOI) Link to item

Elliptocytosis, multiple lipomatosis, and biological false-postive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and 58 were typed for four electrophoretic enzyme markers. Likelihood analysis of the pedigree data confirmed independent dominant inheritance for elliptocytosis and lipomatosis. BFPSTS appears dominant, but the analysis was inconclusive. No linkages were found between any disease gene and any marker gene. Two female pedigree members with BFPSTS developed systemic lupus erythematosus, a finding in agreement with the previously described association. The analysis did not lead to any conclusions about the causal relationship between the two traits.

Duke Scholars

Joe Brice Weinberg
Author Joe Brice Weinberg Medicine, Hematology

Published In

Am J Med Genet

DOI

10.1002/ajmg.1320050108

ISSN

0148-7299

Publication Date

1980

Volume

5

Issue

1

Start / End Page

57 / 67

Location

United States

Related Subject Headings

  • Syphilis Serodiagnosis
  • Pedigree
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Lipomatosis
  • Humans
  • Genetic Linkage
  • Genes, Recessive
  • Genes, Dominant
 

Citation

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ICMJE
MLA
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Weinberg, J. B., Hasstedt, S. J., Skolnick, M. H., Kimberling, W. J., & Baty, B. (1980). Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis. Am J Med Genet, 5(1), 57–67. https://doi.org/10.1002/ajmg.1320050108
Weinberg, J. B., S. J. Hasstedt, M. H. Skolnick, W. J. Kimberling, and B. Baty. “Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis.” Am J Med Genet 5, no. 1 (1980): 57–67. https://doi.org/10.1002/ajmg.1320050108.
Weinberg JB, Hasstedt SJ, Skolnick MH, Kimberling WJ, Baty B. Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis. Am J Med Genet. 1980;5(1):57–67.
Weinberg, J. B., et al. “Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis.” Am J Med Genet, vol. 5, no. 1, 1980, pp. 57–67. Pubmed, doi:10.1002/ajmg.1320050108.
Weinberg JB, Hasstedt SJ, Skolnick MH, Kimberling WJ, Baty B. Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis. Am J Med Genet. 1980;5(1):57–67.

Published In

Am J Med Genet

DOI

10.1002/ajmg.1320050108

ISSN

0148-7299

Publication Date

1980

Volume

5

Issue

1

Start / End Page

57 / 67

Location

United States

Related Subject Headings

  • Syphilis Serodiagnosis
  • Pedigree
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Lipomatosis
  • Humans
  • Genetic Linkage
  • Genes, Recessive
  • Genes, Dominant