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Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.

Publication ,  Journal Article
Anstey, NM; Weinberg, JB; Hassanali, MY; Mwaikambo, ED; Manyenga, D; Misukonis, MA; Arnelle, DR; Hollis, D; McDonald, MI; Granger, DL
Published in: J Exp Med
August 1, 1996

Nitric oxide (NO)-related activity has been shown to be protective against Plasmodium falciparum in vitro. It has been hypothesized, however, that excess NO production contributes to the pathogenesis of cerebral malaria. The purpose of this study was to compare markers of NO production [urinary and plasma nitrate + nitrite (NOx)], leukocyte-inducible nitric oxide synthase type 2 (NOS2), and plasma TNF-alpha and IL-10 levels with disease severity in 191 Tanzanian children with and without malaria. Urine NOx excretion and plasma NOx levels (corrected for renal impairment) were inversely related to disease severity, with levels highest in subclinical infection and lowest in fatal cerebral malaria. Results could not be explained by differences in dietary nitrate ingestion among the groups. Plasma levels of IL-10, a cytokine known to suppress NO synthesis, increased with disease severity. Leukocyte NOS2 antigen was detectable in all control children tested and in all those with subclinical infection, but was undetectable in all but one subject with cerebral malaria. This suppression of NO synthesis in cerebral malaria may contribute to pathogenesis. In contrast, high fasting NOx levels and leukocyte NOS2 in healthy controls and asymptomatic infection suggest that increased NO synthesis might protect against clinical disease. NO appears to have a protective rather than pathological role in African children with malaria.

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Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

August 1, 1996

Volume

184

Issue

2

Start / End Page

557 / 567

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tanzania
  • Prospective Studies
  • Nitrites
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Nitrates
  • Male
  • Malaria
  • Leukocytes
 

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Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., … Granger, D. L. (1996). Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med, 184(2), 557–567. https://doi.org/10.1084/jem.184.2.557
Anstey, N. M., J. B. Weinberg, M. Y. Hassanali, E. D. Mwaikambo, D. Manyenga, M. A. Misukonis, D. R. Arnelle, D. Hollis, M. I. McDonald, and D. L. Granger. “Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.J Exp Med 184, no. 2 (August 1, 1996): 557–67. https://doi.org/10.1084/jem.184.2.557.
Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, Misukonis MA, et al. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med. 1996 Aug 1;184(2):557–67.
Anstey, N. M., et al. “Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.J Exp Med, vol. 184, no. 2, Aug. 1996, pp. 557–67. Pubmed, doi:10.1084/jem.184.2.557.
Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, Misukonis MA, Arnelle DR, Hollis D, McDonald MI, Granger DL. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med. 1996 Aug 1;184(2):557–567.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

August 1, 1996

Volume

184

Issue

2

Start / End Page

557 / 567

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tanzania
  • Prospective Studies
  • Nitrites
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Nitrates
  • Male
  • Malaria
  • Leukocytes