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Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.

Publication ,  Journal Article
Lopansri, BK; Anstey, NM; Weinberg, JB; Stoddard, GJ; Hobbs, MR; Levesque, MC; Mwaikambo, ED; Granger, DL
Published in: Lancet
February 22, 2003

Nitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria. Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthesis of L-arginine, the substrate for NO synthesis. We therefore postulated that L-arginine concentrations would be low in individuals with cerebral malaria. We measured concentrations of L-arginine in cryopreserved plasma samples from Tanzanian children with and without malaria. L-arginine concentrations were low in individuals with cerebral malaria (mean 46 micromol/L, SD 14), intermediate in those with uncomplicated malaria (70 micromol/L, 20), and within the normal range in healthy controls (122 micromol/L, 22; p<0.0001). Analysis by logistic regression showed that hypoargininaemia was significantly associated with cerebral malaria case-fatality. Hypoargininaemia may contribute to limited NO production in children with cerebral malaria and to severe disease.

Duke Scholars

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

February 22, 2003

Volume

361

Issue

9358

Start / End Page

676 / 678

Location

England

Related Subject Headings

  • Tanzania
  • Nitric Oxide
  • Male
  • Malaria, Cerebral
  • Logistic Models
  • Humans
  • General & Internal Medicine
  • Female
  • Child, Preschool
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Lopansri, B. K., Anstey, N. M., Weinberg, J. B., Stoddard, G. J., Hobbs, M. R., Levesque, M. C., … Granger, D. L. (2003). Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet, 361(9358), 676–678. https://doi.org/10.1016/S0140-6736(03)12564-0
Lopansri, Bert K., Nicholas M. Anstey, J Brice Weinberg, Gregory J. Stoddard, Maurine R. Hobbs, Marc C. Levesque, Esther D. Mwaikambo, and Donald L. Granger. “Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.Lancet 361, no. 9358 (February 22, 2003): 676–78. https://doi.org/10.1016/S0140-6736(03)12564-0.
Lopansri BK, Anstey NM, Weinberg JB, Stoddard GJ, Hobbs MR, Levesque MC, et al. Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet. 2003 Feb 22;361(9358):676–8.
Lopansri, Bert K., et al. “Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.Lancet, vol. 361, no. 9358, Feb. 2003, pp. 676–78. Pubmed, doi:10.1016/S0140-6736(03)12564-0.
Lopansri BK, Anstey NM, Weinberg JB, Stoddard GJ, Hobbs MR, Levesque MC, Mwaikambo ED, Granger DL. Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet. 2003 Feb 22;361(9358):676–678.
Journal cover image

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

February 22, 2003

Volume

361

Issue

9358

Start / End Page

676 / 678

Location

England

Related Subject Headings

  • Tanzania
  • Nitric Oxide
  • Male
  • Malaria, Cerebral
  • Logistic Models
  • Humans
  • General & Internal Medicine
  • Female
  • Child, Preschool
  • Case-Control Studies