Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.
Publication
, Journal Article
Levesque, MC; Chen, Y; Beasley, BE; O'Loughlin, CW; Gockerman, JP; Moore, JO; Weinberg, JB
Published in: Leuk Res
January 2006
B cell chronic lymphocytic leukemia (CLL) CD38 expression is variable and may predict outcome. Inducible nitric oxide synthase (NOS2) expression regulates CLL cell apoptosis. IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression. We compared IL-4 and IFN-gamma serum levels between CLL patients and normal individuals, and determined whether serum IL-4 and IFN-gamma levels correlated with CLL cell CD38 expression and NOS enzyme activity. IL-4 levels, but not IFN-gamma levels, differed between normal individuals and CLL patients. Furthermore, there was an association of IL-4 levels, but not IFN-gamma levels, with CD38 and NOS2 expression in CLL patients.
Duke Scholars
Published In
Leuk Res
DOI
ISSN
0145-2126
Publication Date
January 2006
Volume
30
Issue
1
Start / End Page
24 / 28
Location
England
Related Subject Headings
- Prognosis
- Nitric Oxide Synthase Type II
- Middle Aged
- Male
- Leukemia, Lymphocytic, Chronic, B-Cell
- Interleukin-4
- Interferon-gamma
- Immunology
- Humans
- Gene Expression Regulation, Leukemic
Citation
APA
Chicago
ICMJE
MLA
NLM
Levesque, M. C., Chen, Y., Beasley, B. E., O’Loughlin, C. W., Gockerman, J. P., Moore, J. O., & Weinberg, J. B. (2006). Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels. Leuk Res, 30(1), 24–28. https://doi.org/10.1016/j.leukres.2005.05.022
Levesque, Marc C., Youwei Chen, Bethany E. Beasley, Charles W. O’Loughlin, Jon P. Gockerman, Joseph O. Moore, and J Brice Weinberg. “Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.” Leuk Res 30, no. 1 (January 2006): 24–28. https://doi.org/10.1016/j.leukres.2005.05.022.
Levesque MC, Chen Y, Beasley BE, O’Loughlin CW, Gockerman JP, Moore JO, et al. Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels. Leuk Res. 2006 Jan;30(1):24–8.
Levesque, Marc C., et al. “Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.” Leuk Res, vol. 30, no. 1, Jan. 2006, pp. 24–28. Pubmed, doi:10.1016/j.leukres.2005.05.022.
Levesque MC, Chen Y, Beasley BE, O’Loughlin CW, Gockerman JP, Moore JO, Weinberg JB. Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels. Leuk Res. 2006 Jan;30(1):24–28.
Published In
Leuk Res
DOI
ISSN
0145-2126
Publication Date
January 2006
Volume
30
Issue
1
Start / End Page
24 / 28
Location
England
Related Subject Headings
- Prognosis
- Nitric Oxide Synthase Type II
- Middle Aged
- Male
- Leukemia, Lymphocytic, Chronic, B-Cell
- Interleukin-4
- Interferon-gamma
- Immunology
- Humans
- Gene Expression Regulation, Leukemic