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Oxygen, nitric oxide and articular cartilage.

Publication ,  Journal Article
Fermor, B; Christensen, SE; Youn, I; Cernanec, JM; Davies, CM; Weinberg, JB
Published in: Eur Cell Mater
April 11, 2007

Molecular oxygen is required for the production of nitric oxide (NO), a pro-inflammatory mediator that is associated with osteoarthritis and rheumatoid arthritis. To date there has been little consideration of the role of oxygen tension in the regulation of nitric oxide production associated with arthritis. Oxygen tension may be particularly relevant to articular cartilage since it is avascular and therefore exists at a reduced oxygen tension. The superficial zone exists at approximately 6% O2, while the deep zone exists at less than 1% O2. Furthermore, oxygen tension can alter matrix synthesis, and the material properties of articular cartilage in vitro. The increase in nitric oxide associated with arthritis can be caused by pro-inflammatory cytokines and mechanical stress. Oxygen tension significantly alters endogenous NO production in articular cartilage, as well as the stimulation of NO in response to both mechanical loading and pro-inflammatory cytokines. Mechanical loading and pro-inflammatory cytokines also increase the production of prostaglandin E2 (PGE2). There is a complex interaction between NO and PGE2, and oxygen tension can alter this interaction. These findings suggest that the relatively low levels of oxygen within the joint may have significant influences on the metabolic activity, and inflammatory response of cartilage as compared to ambient levels. A better understanding of the role of oxygen in the production of inflammatory mediators in response to mechanical loading, or pro-inflammatory cytokines, may aid in the development of strategies for therapeutic intervention in arthritis.

Duke Scholars

Published In

Eur Cell Mater

DOI

EISSN

1473-2262

Publication Date

April 11, 2007

Volume

13

Start / End Page

56 / 65

Location

United States

Related Subject Headings

  • Swine
  • Stress, Mechanical
  • Oxygen
  • Osteoarthritis
  • Nitric Oxide
  • Inflammation Mediators
  • Inflammation
  • Female
  • Cartilage, Articular
  • Biomedical Engineering
 

Citation

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Fermor, B., Christensen, S. E., Youn, I., Cernanec, J. M., Davies, C. M., & Weinberg, J. B. (2007). Oxygen, nitric oxide and articular cartilage. Eur Cell Mater, 13, 56–65. https://doi.org/10.22203/ecm.v013a06
Fermor, B., S. E. Christensen, I. Youn, J. M. Cernanec, C. M. Davies, and J. B. Weinberg. “Oxygen, nitric oxide and articular cartilage.Eur Cell Mater 13 (April 11, 2007): 56–65. https://doi.org/10.22203/ecm.v013a06.
Fermor B, Christensen SE, Youn I, Cernanec JM, Davies CM, Weinberg JB. Oxygen, nitric oxide and articular cartilage. Eur Cell Mater. 2007 Apr 11;13:56–65.
Fermor, B., et al. “Oxygen, nitric oxide and articular cartilage.Eur Cell Mater, vol. 13, Apr. 2007, pp. 56–65. Pubmed, doi:10.22203/ecm.v013a06.
Fermor B, Christensen SE, Youn I, Cernanec JM, Davies CM, Weinberg JB. Oxygen, nitric oxide and articular cartilage. Eur Cell Mater. 2007 Apr 11;13:56–65.

Published In

Eur Cell Mater

DOI

EISSN

1473-2262

Publication Date

April 11, 2007

Volume

13

Start / End Page

56 / 65

Location

United States

Related Subject Headings

  • Swine
  • Stress, Mechanical
  • Oxygen
  • Osteoarthritis
  • Nitric Oxide
  • Inflammation Mediators
  • Inflammation
  • Female
  • Cartilage, Articular
  • Biomedical Engineering