p47 GTPases: regulators of immunity to intracellular pathogens.
Publication
, Journal Article
Taylor, GA; Feng, CG; Sher, A
Published in: Nat Rev Immunol
February 2004
Activation of the innate immune system by interferon-gamma (IFN-gamma is crucial for host resistance to infection. IFN-gamma induces the expression of a wide range of mediators that undermine the ability of pathogens to survive in host cells, including a newly discovered family of 47-kDa GTPases. Elimination of different p47 GTPases in mice by gene targeting severely cripples IFN-gamma-regulated defence against Toxoplasma gondii, Listeria monocytogenes, Mycobacterium spp. and other pathogens. In this article, we review our understanding of the role of p47 GTPases in resistance to intracellular infection and discuss the present evidence concerning their mode of action.
Duke Scholars
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Published In
Nat Rev Immunol
DOI
ISSN
1474-1733
Publication Date
February 2004
Volume
4
Issue
2
Start / End Page
100 / 109
Location
England
Related Subject Headings
- Virus Diseases
- Protozoan Infections
- Interferon-gamma
- Immunology
- Immunity, Innate
- Humans
- GTP Phosphohydrolases
- Bacterial Infections
- Animals
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Taylor, G. A., Feng, C. G., & Sher, A. (2004). p47 GTPases: regulators of immunity to intracellular pathogens. Nat Rev Immunol, 4(2), 100–109. https://doi.org/10.1038/nri1270
Taylor, Gregory A., Carl G. Feng, and Alan Sher. “p47 GTPases: regulators of immunity to intracellular pathogens.” Nat Rev Immunol 4, no. 2 (February 2004): 100–109. https://doi.org/10.1038/nri1270.
Taylor GA, Feng CG, Sher A. p47 GTPases: regulators of immunity to intracellular pathogens. Nat Rev Immunol. 2004 Feb;4(2):100–9.
Taylor, Gregory A., et al. “p47 GTPases: regulators of immunity to intracellular pathogens.” Nat Rev Immunol, vol. 4, no. 2, Feb. 2004, pp. 100–09. Pubmed, doi:10.1038/nri1270.
Taylor GA, Feng CG, Sher A. p47 GTPases: regulators of immunity to intracellular pathogens. Nat Rev Immunol. 2004 Feb;4(2):100–109.
Published In
Nat Rev Immunol
DOI
ISSN
1474-1733
Publication Date
February 2004
Volume
4
Issue
2
Start / End Page
100 / 109
Location
England
Related Subject Headings
- Virus Diseases
- Protozoan Infections
- Interferon-gamma
- Immunology
- Immunity, Innate
- Humans
- GTP Phosphohydrolases
- Bacterial Infections
- Animals
- 3204 Immunology