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Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease.

Publication ,  Journal Article
Parekh, PI; Blumenthal, JA; Babyak, MA; LaCaille, R; Rowe, S; Dancel, L; Carney, RM; Davis, RD; Palmer, S; INSPIRE Investigators,
Published in: Psychosom Med
2005

OBJECTIVE: This study examined the relationship between cognitive functioning and the severity of underlying lung disease in patients awaiting lung transplantation. METHODS: Ninety-four patients with end-stage lung disease completed a test battery to assess cognitive performance in two domains: executive functioning/attention (Trails A and B, COWA, Animal Naming, Stroop Color-Word Test, Digit Symbol, and the 2 & 7 Test) and verbal memory (Digit Span-Backward and Forward, WMS-R Logical Memory and Paired Verbal Associates). RESULTS: Thirty-seven percent of the patients demonstrated moderate to severe cognitive impairment data on two or more tests. Adjusting for age and education, there were no statistically significant differences on executive functioning or verbal memory as a function of specific lung disease diagnosis. Lower PCO2 values were associated with better cognitive performance on latent measures of executive functioning and attention (p = .006) and verbal memory (p = .009), whereas higher PO2 values tended to be associated with better performance on the executive functioning/attention measure (p = .064). Distance walked in 6 minutes was positively related to verbal memory (p < .023). CONCLUSIONS: Impaired neurocognitive functioning may be relatively common in patients awaiting lung transplantation and is associated with ineffective pulmonary gas exchange and reduced exercise tolerance.

Duke Scholars

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2005

Volume

67

Issue

3

Start / End Page

425 / 432

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Respiratory Insufficiency
  • Pulmonary Gas Exchange
  • Psychological Tests
  • Psychiatry
  • Preoperative Care
  • Middle Aged
  • Memory
  • Male
  • Lung Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Parekh, P. I., Blumenthal, J. A., Babyak, M. A., LaCaille, R., Rowe, S., Dancel, L., … INSPIRE Investigators, . (2005). Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease. Psychosom Med, 67(3), 425–432. https://doi.org/10.1097/01.psy.0000160479.99765.18
Parekh, Priti I., James A. Blumenthal, Michael A. Babyak, Rick LaCaille, Sarah Rowe, Liz Dancel, Robert M. Carney, R Duane Davis, Scott Palmer, and Scott INSPIRE Investigators. “Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease.Psychosom Med 67, no. 3 (2005): 425–32. https://doi.org/10.1097/01.psy.0000160479.99765.18.
Parekh PI, Blumenthal JA, Babyak MA, LaCaille R, Rowe S, Dancel L, et al. Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease. Psychosom Med. 2005;67(3):425–32.
Parekh, Priti I., et al. “Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease.Psychosom Med, vol. 67, no. 3, 2005, pp. 425–32. Pubmed, doi:10.1097/01.psy.0000160479.99765.18.
Parekh PI, Blumenthal JA, Babyak MA, LaCaille R, Rowe S, Dancel L, Carney RM, Davis RD, Palmer S, INSPIRE Investigators. Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease. Psychosom Med. 2005;67(3):425–432.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2005

Volume

67

Issue

3

Start / End Page

425 / 432

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Respiratory Insufficiency
  • Pulmonary Gas Exchange
  • Psychological Tests
  • Psychiatry
  • Preoperative Care
  • Middle Aged
  • Memory
  • Male
  • Lung Transplantation