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Cognitive decline after major noncardiac operations: a preliminary prospective study.

Publication ,  Journal Article
Grichnik, KP; Ijsselmuiden, AJ; D'Amico, TA; Harpole, DH; White, WD; Blumenthal, JA; Newman, MF
Published in: Ann Thorac Surg
November 1999

BACKGROUND: Cardiac operations frequently are complicated by postoperative cognitive decline. Less common and less studied is postoperative cognitive decline after noncardiac surgery, so we determined its incidence, severity, and possible predictors. METHODS: Twenty-nine patients who had thoracic and vascular procedures were studied. A neurocognitive test battery was administered preoperatively and 6 to 12 weeks postoperatively. A change score (preoperative minus postoperative) was calculated for each measure in each individual. Cognitive deficit (a measure of incidence) was defined as a 20% decrement in 20% or more of the completed tests. The average scores of all tests and the average decline (a measure of severity) were determined. RESULTS: The incidence of cognitive deficit was 44.8%. Overall the severity of the decline was an average of 15% decline. In the 44.8% of patients who had cognitive deficit, the severity was 24.7%. Multivariable predictors of cognitive decline were age (for incidence and severity) and years of education (for severity). CONCLUSIONS: Cognitive decline after noncardiac operations is a frequent complication of surgical procedures. The severity could preclude successful return to a preoperative lifestyle.

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Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

November 1999

Volume

68

Issue

5

Start / End Page

1786 / 1791

Location

Netherlands

Related Subject Headings

  • Thoracic Diseases
  • Risk Factors
  • Respiratory System
  • Postoperative Complications
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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Grichnik, K. P., Ijsselmuiden, A. J., D’Amico, T. A., Harpole, D. H., White, W. D., Blumenthal, J. A., & Newman, M. F. (1999). Cognitive decline after major noncardiac operations: a preliminary prospective study. Ann Thorac Surg, 68(5), 1786–1791. https://doi.org/10.1016/s0003-4975(99)00992-3
Grichnik, K. P., A. J. Ijsselmuiden, T. A. D’Amico, D. H. Harpole, W. D. White, J. A. Blumenthal, and M. F. Newman. “Cognitive decline after major noncardiac operations: a preliminary prospective study.Ann Thorac Surg 68, no. 5 (November 1999): 1786–91. https://doi.org/10.1016/s0003-4975(99)00992-3.
Grichnik KP, Ijsselmuiden AJ, D’Amico TA, Harpole DH, White WD, Blumenthal JA, et al. Cognitive decline after major noncardiac operations: a preliminary prospective study. Ann Thorac Surg. 1999 Nov;68(5):1786–91.
Grichnik, K. P., et al. “Cognitive decline after major noncardiac operations: a preliminary prospective study.Ann Thorac Surg, vol. 68, no. 5, Nov. 1999, pp. 1786–91. Pubmed, doi:10.1016/s0003-4975(99)00992-3.
Grichnik KP, Ijsselmuiden AJ, D’Amico TA, Harpole DH, White WD, Blumenthal JA, Newman MF. Cognitive decline after major noncardiac operations: a preliminary prospective study. Ann Thorac Surg. 1999 Nov;68(5):1786–1791.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

November 1999

Volume

68

Issue

5

Start / End Page

1786 / 1791

Location

Netherlands

Related Subject Headings

  • Thoracic Diseases
  • Risk Factors
  • Respiratory System
  • Postoperative Complications
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female