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Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation.

Publication ,  Journal Article
Guichardant, M; Michel, M; Borel, C; Fay, L; Crozier, G; Magnolato, D; Finot, PA
Published in: Agents Actions Suppl
1992
Published version (DOI) Link to item

An acetylenic fatty acid: 9,12,15-octadecatrien-6-ynoic acid (dicranin), extracted from Dicranum Scoparium was preincubated with platelets stimulated by exogenous arachidonic acid (20:4 n-6). Dicranin (10(-4) M) weakly inhibited the cyclooxygenase activity as assessed by measurement of 12-hydroxy-heptadecatrienoic acid (HHT) In contrast, the 12-hydroxy-eicosatetraenoic acid (12-HETE) synthesized by the 12-lipoxygenase was strongly increased by about 650%. The same effects were observed with 10(-6) M of dicranin but to a lesser extent. The main platelet hydroxylated dicranin metabolite determined by GC-MS was a 13-hydroxy derivative Platelet aggregation induced either by thrombin or by arachidonic acid or by U46619, an structural PGH2 analogue was inhibited by 10(-4) M of dicranin.

Duke Scholars

Cecil Orm Borel III
Author Cecil Orm Borel III Anesthesiology, Neuroanesthesia

Published In

Agents Actions Suppl

DOI

10.1007/978-3-0348-7262-1_30

ISSN

0379-0363

Publication Date

1992

Volume

37

Start / End Page

215 / 221

Location

Switzerland

Related Subject Headings

  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Lipoxygenase Inhibitors
  • Linolenic Acids
  • In Vitro Techniques
  • Hydroxyeicosatetraenoic Acids
  • Humans
  • Fatty Acids, Unsaturated
  • Cyclooxygenase Inhibitors
  • Blood Platelets
 

Citation

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MLA
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Guichardant, M., Michel, M., Borel, C., Fay, L., Crozier, G., Magnolato, D., & Finot, P. A. (1992). Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation. Agents Actions Suppl, 37, 215–221. https://doi.org/10.1007/978-3-0348-7262-1_30
Guichardant, M., M. Michel, C. Borel, L. Fay, G. Crozier, D. Magnolato, and P. A. Finot. “Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation.” Agents Actions Suppl 37 (1992): 215–21. https://doi.org/10.1007/978-3-0348-7262-1_30.
Guichardant M, Michel M, Borel C, Fay L, Crozier G, Magnolato D, et al. Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation. Agents Actions Suppl. 1992;37:215–21.
Guichardant, M., et al. “Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation.” Agents Actions Suppl, vol. 37, 1992, pp. 215–21. Pubmed, doi:10.1007/978-3-0348-7262-1_30.
Guichardant M, Michel M, Borel C, Fay L, Crozier G, Magnolato D, Finot PA. Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation. Agents Actions Suppl. 1992;37:215–221.

Published In

Agents Actions Suppl

DOI

10.1007/978-3-0348-7262-1_30

ISSN

0379-0363

Publication Date

1992

Volume

37

Start / End Page

215 / 221

Location

Switzerland

Related Subject Headings

  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Lipoxygenase Inhibitors
  • Linolenic Acids
  • In Vitro Techniques
  • Hydroxyeicosatetraenoic Acids
  • Humans
  • Fatty Acids, Unsaturated
  • Cyclooxygenase Inhibitors
  • Blood Platelets