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Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.

Publication ,  Journal Article
Shuler, RK; Hauser, MA; Caldwell, J; Gallins, P; Schmidt, S; Scott, WK; Agarwal, A; Haines, JL; Pericak-Vance, MA; Postel, EA
Published in: Arch Ophthalmol
January 2007

OBJECTIVE: To compare phenotypes of 2 age-related macular degeneration (AMD) susceptibility genes: LOC387715 and complement factor H (CFH). METHODS: Phenotypes of 755 AMD cases were characterized. The number of LOC387715 (T allele at rs10490924, or A69S) and CFH (T1277C at rs1061170, or Y402H) risk alleles were determined in each case. Individuals were divided into 5 groups by genotype: group 1, LOC-/- CFH-/-; group 2, LOC+/- CFH-/- or LOC+/+ CFH-/-; group 3, LOC-/- CFH+/- or LOC-/- CFH+/+; group 4, LOC+/- CFH+/-, LOC+/+ CFH+/-, or LOC+/- CFH+/+; and group 5, LOC+/+ CFH+/+. RESULTS: Signs of neovascular AMD including grade (P = .002), pigment epithelial detachment (P = .001), and subretinal hemorrhage (P<.001) demonstrated significant association with groups 2, 4, and 5 vs groups 1 and 3. Group 5 had a significantly younger mean age (72.3 years) compared with other groups (P = .002). CONCLUSIONS: The AMD cases possessing the LOC387715 (rs10490924) variant may have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD.

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Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

January 2007

Volume

125

Issue

1

Start / End Page

63 / 67

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Ophthalmology & Optometry
  • Male
  • Macular Degeneration
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shuler, R. K., Hauser, M. A., Caldwell, J., Gallins, P., Schmidt, S., Scott, W. K., … Postel, E. A. (2007). Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism. Arch Ophthalmol, 125(1), 63–67. https://doi.org/10.1001/archopht.125.1.63
Shuler, R Keith, Michael A. Hauser, Jennifer Caldwell, Paul Gallins, Silke Schmidt, William K. Scott, Anita Agarwal, Jonathan L. Haines, Margaret A. Pericak-Vance, and Eric A. Postel. “Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.Arch Ophthalmol 125, no. 1 (January 2007): 63–67. https://doi.org/10.1001/archopht.125.1.63.
Shuler RK, Hauser MA, Caldwell J, Gallins P, Schmidt S, Scott WK, et al. Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism. Arch Ophthalmol. 2007 Jan;125(1):63–7.
Shuler, R. Keith, et al. “Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.Arch Ophthalmol, vol. 125, no. 1, Jan. 2007, pp. 63–67. Pubmed, doi:10.1001/archopht.125.1.63.
Shuler RK, Hauser MA, Caldwell J, Gallins P, Schmidt S, Scott WK, Agarwal A, Haines JL, Pericak-Vance MA, Postel EA. Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism. Arch Ophthalmol. 2007 Jan;125(1):63–67.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

January 2007

Volume

125

Issue

1

Start / End Page

63 / 67

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Ophthalmology & Optometry
  • Male
  • Macular Degeneration
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female