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Ductal carcinoma in situ: a review of recent advances.

Publication ,  Journal Article
Tang, P; Hajdu, SI; Lyman, GH
Published in: Curr Opin Obstet Gynecol
February 2007

PURPOSE OF REVIEW: This review summarizes recent findings on ductal carcinoma in situ of the breast and their impact on prognosis and management of the disease. RECENT FINDINGS: Great advances have been made in our understanding of ductal carcinoma in situ. Nuclear grading is probably the most important pathological factor that affects clinical outcome and correlates with distinct genetic pathways. Identifying key molecules in each pathway may provide better markers for prognostic, predictive and therapeutic purposes. Not all cases of ductal carcinoma in situ will progress to invasive ductal carcinoma, and identifying this subgroup of patients should lead to a reduction of overtreatment. Progenitor cell theory at the cellular level and sick lobe theory at the architectural level may help provide a better understanding of ductal carcinoma in situ from a different perspective and facilitate the development of individualized therapy. Prevention of local recurrence is the primary goal for treatment. Debate continues, however, on the use of radiotherapy, hormonal therapy, and sentinel lymph node biopsy. A panel of molecular markers may be needed for accurately predicting clinical outcome for the disease. SUMMARY: Understanding the carcinogenesis of ductal carcinoma in situ at the molecular level may lead to an optimal individualized therapy with minimal over or undertreatment.

Duke Scholars

Published In

Curr Opin Obstet Gynecol

DOI

ISSN

1040-872X

Publication Date

February 2007

Volume

19

Issue

1

Start / End Page

63 / 67

Location

England

Related Subject Headings

  • Prognosis
  • Obstetrics & Reproductive Medicine
  • Neoplasm Recurrence, Local
  • Mastectomy, Segmental
  • Humans
  • Female
  • Carcinoma, Intraductal, Noninfiltrating
  • Breast Neoplasms
  • Biomarkers
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tang, P., Hajdu, S. I., & Lyman, G. H. (2007). Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol, 19(1), 63–67. https://doi.org/10.1097/GCO.0b013e3280114a3a
Tang, Ping, Steven I. Hajdu, and Gary H. Lyman. “Ductal carcinoma in situ: a review of recent advances.Curr Opin Obstet Gynecol 19, no. 1 (February 2007): 63–67. https://doi.org/10.1097/GCO.0b013e3280114a3a.
Tang P, Hajdu SI, Lyman GH. Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol. 2007 Feb;19(1):63–7.
Tang, Ping, et al. “Ductal carcinoma in situ: a review of recent advances.Curr Opin Obstet Gynecol, vol. 19, no. 1, Feb. 2007, pp. 63–67. Pubmed, doi:10.1097/GCO.0b013e3280114a3a.
Tang P, Hajdu SI, Lyman GH. Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol. 2007 Feb;19(1):63–67.

Published In

Curr Opin Obstet Gynecol

DOI

ISSN

1040-872X

Publication Date

February 2007

Volume

19

Issue

1

Start / End Page

63 / 67

Location

England

Related Subject Headings

  • Prognosis
  • Obstetrics & Reproductive Medicine
  • Neoplasm Recurrence, Local
  • Mastectomy, Segmental
  • Humans
  • Female
  • Carcinoma, Intraductal, Noninfiltrating
  • Breast Neoplasms
  • Biomarkers
  • 1114 Paediatrics and Reproductive Medicine