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Obesity, body fat distribution, and sex hormones in breast cancer patients.

Publication ,  Journal Article
Schapira, DV; Kumar, NB; Lyman, GH
Published in: Cancer
April 15, 1991

This study addresses the relationship between female sex hormones, obesity, body fat distribution, and breast cancer. Increasing obesity correlated with a progressive fall in sex hormone-binding globulin (SHBG) level and an increase in testosterone level. Premenopausal breast cancer patients were found to have significantly lower levels of SHBG compared with age-matched and weight-matched controls. This difference in SHBG level was not noted in postmenopausal breast cancer patients. The SHBG level decreased with increasing upper body fat localization in breast cancer patients and controls. This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 15, 1991

Volume

67

Issue

8

Start / End Page

2215 / 2218

Location

United States

Related Subject Headings

  • Testosterone
  • Sex Hormone-Binding Globulin
  • Oncology & Carcinogenesis
  • Obesity
  • Middle Aged
  • Menopause
  • Humans
  • Gonadal Steroid Hormones
  • Female
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Schapira, D. V., Kumar, N. B., & Lyman, G. H. (1991). Obesity, body fat distribution, and sex hormones in breast cancer patients. Cancer, 67(8), 2215–2218. https://doi.org/10.1002/1097-0142(19910415)67:8<2215::aid-cncr2820670836>3.0.co;2-q
Schapira, D. V., N. B. Kumar, and G. H. Lyman. “Obesity, body fat distribution, and sex hormones in breast cancer patients.Cancer 67, no. 8 (April 15, 1991): 2215–18. https://doi.org/10.1002/1097-0142(19910415)67:8<2215::aid-cncr2820670836>3.0.co;2-q.
Schapira DV, Kumar NB, Lyman GH. Obesity, body fat distribution, and sex hormones in breast cancer patients. Cancer. 1991 Apr 15;67(8):2215–8.
Schapira, D. V., et al. “Obesity, body fat distribution, and sex hormones in breast cancer patients.Cancer, vol. 67, no. 8, Apr. 1991, pp. 2215–18. Pubmed, doi:10.1002/1097-0142(19910415)67:8<2215::aid-cncr2820670836>3.0.co;2-q.
Schapira DV, Kumar NB, Lyman GH. Obesity, body fat distribution, and sex hormones in breast cancer patients. Cancer. 1991 Apr 15;67(8):2215–2218.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 15, 1991

Volume

67

Issue

8

Start / End Page

2215 / 2218

Location

United States

Related Subject Headings

  • Testosterone
  • Sex Hormone-Binding Globulin
  • Oncology & Carcinogenesis
  • Obesity
  • Middle Aged
  • Menopause
  • Humans
  • Gonadal Steroid Hormones
  • Female
  • Breast Neoplasms