Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish.
Appendage regeneration is defined by rapid changes in gene expression that achieve dramatic developmental effects, suggesting involvement of microRNAs (miRNAs). Here, we find dynamic regulation of many miRNAs during zebrafish fin regeneration. In particular, miR-133 levels are high in uninjured fins but low during regeneration. When regeneration was blocked by Fibroblast growth factor (Fgf) receptor inhibition, high miR-133 levels were quickly restored. Experimentally increasing amounts of miR-133 attenuated fin regeneration. Conversely, miR-133 antagonism during Fgf receptor inhibition accelerated regeneration through increased proliferation within the regeneration blastema. The Mps1 kinase, an established positive regulator of blastemal proliferation, is an in vivo target of miR-133. Our findings identify miRNA depletion as a new regulatory mechanism for complex tissue regeneration.
Duke Scholars
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- Zebrafish Proteins
- Zebrafish
- Reverse Transcriptase Polymerase Chain Reaction
- Regeneration
- Receptors, Fibroblast Growth Factor
- RNA, Messenger
- Protein-Tyrosine Kinases
- Protein Serine-Threonine Kinases
- MicroRNAs
- Gene Expression Regulation, Developmental
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Zebrafish Proteins
- Zebrafish
- Reverse Transcriptase Polymerase Chain Reaction
- Regeneration
- Receptors, Fibroblast Growth Factor
- RNA, Messenger
- Protein-Tyrosine Kinases
- Protein Serine-Threonine Kinases
- MicroRNAs
- Gene Expression Regulation, Developmental