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Neonatal alloimmune thrombocytopenic purpura.

Publication ,  Journal Article
Deaver, JE; Leppert, PC; Zaroulis, CG
Published in: Am J Perinatol
April 1986

We reviewed 58 literature reports of neonatal alloimmune thrombocytopenic purpura (NAITP). The mortality rate was 9%. The total incidence of suspected intracranial hemorrhage was 28%. We reviewed 17 sibship cases for the relation of birth order to treatment and outcome. Among firstborn affected infants (n = 17) the mortality rate and incidence of central nervous system sequelae were 24 and 47%, respectively, compared to rates of 5 and 15%, respectively, in their younger affected siblings (n = 20). The improved outcome in the latter group appeared to be related to more frequent cesarean section delivery and more frequent and earlier use of corticosteroids and maternal platelet transfusions in the neonate. Sensitive assays of maternal platelet alloantibody are now available, but they lack specificity for NAITP affecting the current gestation. There are two reports in which sensitive assays revealed rising titers of maternal platelet alloantibody during advancing gestation. We propose further study to determine if this is specific for the antepartum diagnosis of NAITP.

Duke Scholars

Published In

Am J Perinatol

DOI

ISSN

0735-1631

Publication Date

April 1986

Volume

3

Issue

2

Start / End Page

127 / 131

Location

United States

Related Subject Headings

  • Purpura, Thrombocytopenic
  • Pregnancy
  • Platelet Transfusion
  • Obstetrics & Reproductive Medicine
  • Maternal-Fetal Exchange
  • Isoantibodies
  • Infant, Newborn
  • Humans
  • Female
  • Enzyme-Linked Immunosorbent Assay
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Deaver, J. E., Leppert, P. C., & Zaroulis, C. G. (1986). Neonatal alloimmune thrombocytopenic purpura. Am J Perinatol, 3(2), 127–131. https://doi.org/10.1055/s-2007-999848
Deaver, J. E., P. C. Leppert, and C. G. Zaroulis. “Neonatal alloimmune thrombocytopenic purpura.Am J Perinatol 3, no. 2 (April 1986): 127–31. https://doi.org/10.1055/s-2007-999848.
Deaver JE, Leppert PC, Zaroulis CG. Neonatal alloimmune thrombocytopenic purpura. Am J Perinatol. 1986 Apr;3(2):127–31.
Deaver, J. E., et al. “Neonatal alloimmune thrombocytopenic purpura.Am J Perinatol, vol. 3, no. 2, Apr. 1986, pp. 127–31. Pubmed, doi:10.1055/s-2007-999848.
Deaver JE, Leppert PC, Zaroulis CG. Neonatal alloimmune thrombocytopenic purpura. Am J Perinatol. 1986 Apr;3(2):127–131.
Journal cover image

Published In

Am J Perinatol

DOI

ISSN

0735-1631

Publication Date

April 1986

Volume

3

Issue

2

Start / End Page

127 / 131

Location

United States

Related Subject Headings

  • Purpura, Thrombocytopenic
  • Pregnancy
  • Platelet Transfusion
  • Obstetrics & Reproductive Medicine
  • Maternal-Fetal Exchange
  • Isoantibodies
  • Infant, Newborn
  • Humans
  • Female
  • Enzyme-Linked Immunosorbent Assay