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A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.

Publication ,  Journal Article
Leppert, PC; Catherino, WH; Segars, JH
Published in: Am J Obstet Gynecol
August 2006

This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

August 2006

Volume

195

Issue

2

Start / End Page

415 / 420

Location

United States

Related Subject Headings

  • Wound Healing
  • Uterine Neoplasms
  • Reverse Transcriptase Polymerase Chain Reaction
  • Oligonucleotide Array Sequence Analysis
  • Obstetrics & Reproductive Medicine
  • Leiomyoma
  • Keloid
  • Humans
  • Gene Expression Profiling
  • Female
 

Citation

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Leppert, P. C., Catherino, W. H., & Segars, J. H. (2006). A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am J Obstet Gynecol, 195(2), 415–420. https://doi.org/10.1016/j.ajog.2005.12.059
Leppert, Phyllis C., William H. Catherino, and James H. Segars. “A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.Am J Obstet Gynecol 195, no. 2 (August 2006): 415–20. https://doi.org/10.1016/j.ajog.2005.12.059.
Leppert PC, Catherino WH, Segars JH. A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am J Obstet Gynecol. 2006 Aug;195(2):415–20.
Leppert, Phyllis C., et al. “A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.Am J Obstet Gynecol, vol. 195, no. 2, Aug. 2006, pp. 415–20. Pubmed, doi:10.1016/j.ajog.2005.12.059.
Leppert PC, Catherino WH, Segars JH. A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am J Obstet Gynecol. 2006 Aug;195(2):415–420.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

August 2006

Volume

195

Issue

2

Start / End Page

415 / 420

Location

United States

Related Subject Headings

  • Wound Healing
  • Uterine Neoplasms
  • Reverse Transcriptase Polymerase Chain Reaction
  • Oligonucleotide Array Sequence Analysis
  • Obstetrics & Reproductive Medicine
  • Leiomyoma
  • Keloid
  • Humans
  • Gene Expression Profiling
  • Female