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Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone.

Publication ,  Journal Article
Santos, F; Chan, JC; Krieg, RJ; Niimi, K; Hanna, JD; Foreman, JW; Perkins, AH
Published in: Child Nephrol Urol
1992

The lipid metabolic disorders in chronic renal insufficiency (CRI) are related to increased hepatic lipid synthesis, reduced triglyceride removal coupled with insulin insensitivity and impaired lipoprotein lipase activity. Growth hormone is lipolytic, and the effects of recombinant human growth hormone (rhGH) on the hypercholesterolemia of CRI are unsettled. To test this question, we gave rhGH for 14 days at a dosage of 3 units/day intraperitoneally to two-stage, 5/6 nephrectomized, male Sprague-Dawley rats (n = 18) compared to sex- and age-matched control (n = 27) and CRI (n = 40) rats. At the end of the study, CRI rats and those treated with rhGH had a similar degree of renal impairment, as assessed by serum concentrations (mean +/- SEM) of urea nitrogen (49 +/- 3 vs. 54 +/- 4 mg/dl), creatinine (0.9 +/- 0.0 vs. 1.0 +/- 0.1 mg/dl) and cumulative food intake (311 +/- 8 vs. 290 +/- 12 g). Serum urea nitrogen (16 +/- 4 mg/dl) and creatinine (0.4 +/- 0.1 mg/dl) concentrations as well as food intake (412 +/- 9 g) of control rats were significantly (p < 0.0001) different. Serum cholesterol concentration of CRI rats treated with rhGH (87 +/- 3 mg/dl) was not higher than those of CRI rats (81 +/- 2 mg/dl, p < 0.1338) but was significantly higher than in control rats (55 +/- 3 mg/dl, p < 0.0001). CRI rats treated with rhGH showed a similar serum albumin concentration and lower serum glucose than CRI rats (0.9 +/- 0.1 vs. 0.9 +/- 0.0 g/dl and 144 +/- 4 vs. 163 +/- 3 mg/dl, p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Child Nephrol Urol

ISSN

1012-6694

Publication Date

1992

Volume

12

Issue

4

Start / End Page

182 / 185

Location

Switzerland

Related Subject Headings

  • Urea
  • Triglycerides
  • Serum Albumin
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Male
  • Kidney Failure, Chronic
  • Hypercholesterolemia
  • Growth Hormone
 

Citation

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Santos, F., Chan, J. C., Krieg, R. J., Niimi, K., Hanna, J. D., Foreman, J. W., & Perkins, A. H. (1992). Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone. Child Nephrol Urol, 12(4), 182–185.
Santos, F., J. C. Chan, R. J. Krieg, K. Niimi, J. D. Hanna, J. W. Foreman, and A. H. Perkins. “Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone.Child Nephrol Urol 12, no. 4 (1992): 182–85.
Santos F, Chan JC, Krieg RJ, Niimi K, Hanna JD, Foreman JW, et al. Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone. Child Nephrol Urol. 1992;12(4):182–5.
Santos, F., et al. “Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone.Child Nephrol Urol, vol. 12, no. 4, 1992, pp. 182–85.
Santos F, Chan JC, Krieg RJ, Niimi K, Hanna JD, Foreman JW, Perkins AH. Hypercholesterolemia in rats with chronic renal insufficiency not aggravated by recombinant human growth hormone. Child Nephrol Urol. 1992;12(4):182–185.

Published In

Child Nephrol Urol

ISSN

1012-6694

Publication Date

1992

Volume

12

Issue

4

Start / End Page

182 / 185

Location

Switzerland

Related Subject Headings

  • Urea
  • Triglycerides
  • Serum Albumin
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Male
  • Kidney Failure, Chronic
  • Hypercholesterolemia
  • Growth Hormone