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The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet.

Publication ,  Journal Article
Nakano, M; Kainer, G; Foreman, JW; Ko, DJ; Chan, JC
Published in: Pediatr Res
September 1989

Although the mechanisms underlying the inhibitory effects of chronic renal insufficiency on growth are poorly understood, large doses of growth hormone (GH) have been used to improve growth. The present study examines the effects of rat GH and a reduced (8%) protein diet on 75% nephrectomized weanling rats by measuring changes in growth parameters, food utilization, serum albumin concentration, and muscle water content. Significantly greater improvement in growth was found in the GH-treated uremic rats compared with the uremic controls. The mean percent change in wt, length (nose to tail tip), and cranial biparietal diameter was significantly increased in the GH-treated uremic rats, compared with the uremic controls, but foot length and femur length showed only moderate improvement. Food utilization efficiency and serum albumin concentration were significantly higher in GH-treated uremic rats compared with uremic controls, achieving levels that were not different from sham-operated rats. Muscle water content was not significantly different between GH-treated uremic rats, uremic controls, and sham-operated rats. Thus, rat GH treatment administered at an early age in mild renal insufficiency significantly improved overall growth, food efficiency, and serum albumin concentrations, despite a low protein diet, suggesting that further evaluation of this form of therapy for growth failure of uremia is warranted.

Duke Scholars

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

September 1989

Volume

26

Issue

3

Start / End Page

204 / 207

Location

United States

Related Subject Headings

  • Uremia
  • Serum Albumin
  • Rats, Inbred Strains
  • Rats
  • Pediatrics
  • Growth Hormone
  • Growth
  • Disease Models, Animal
  • Diet
  • Creatinine
 

Citation

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Nakano, M., Kainer, G., Foreman, J. W., Ko, D. J., & Chan, J. C. (1989). The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet. Pediatr Res, 26(3), 204–207. https://doi.org/10.1203/00006450-198909000-00010
Nakano, M., G. Kainer, J. W. Foreman, D. J. Ko, and J. C. Chan. “The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet.Pediatr Res 26, no. 3 (September 1989): 204–7. https://doi.org/10.1203/00006450-198909000-00010.
Nakano M, Kainer G, Foreman JW, Ko DJ, Chan JC. The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet. Pediatr Res. 1989 Sep;26(3):204–7.
Nakano, M., et al. “The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet.Pediatr Res, vol. 26, no. 3, Sept. 1989, pp. 204–07. Pubmed, doi:10.1203/00006450-198909000-00010.
Nakano M, Kainer G, Foreman JW, Ko DJ, Chan JC. The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet. Pediatr Res. 1989 Sep;26(3):204–207.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

September 1989

Volume

26

Issue

3

Start / End Page

204 / 207

Location

United States

Related Subject Headings

  • Uremia
  • Serum Albumin
  • Rats, Inbred Strains
  • Rats
  • Pediatrics
  • Growth Hormone
  • Growth
  • Disease Models, Animal
  • Diet
  • Creatinine