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Genetic analysis of multiplex rheumatoid arthritis families.

Publication ,  Journal Article
Bali, D; Gourley, S; Kostyu, DD; Goel, N; Bruce, I; Bell, A; Walker, DJ; Tran, K; Zhu, DK; Costello, TJ; Amos, CI; Seldin, MF
Published in: Genes Immun
September 1999

To examine the genetic contribution of HLA and non-HLA genes in the etiopathogenesis of rheumatoid arthritis (RA), 60 Caucasian multiplex families were identified and DNA analyzed for over 52 markers including DRB1, DQA1 and DQB1 alleles. Many of the markers were chosen because of close proximity to candidate genes suggested by previous studies or models of pathogenesis. Sibling pair analysis (SIBPAL), relative pair analysis (RELPAL) and linkage studies using two different models of inheritance suggested linkage for the MHC and two additional chromosomal regions: chromosome 2 (D2S443 near CD8 and IGk; 2p13-2p11.1), and chromosome 15 (CYP19-estrogen synthase; 15q15). No support was found for two chromosomal regions, 1p36 and 3q13, recently suggested by other studies. We used transmission disequilibrium testing (TDT), conditional logistic regression, and segregation analysis to study the contributions that the shared epitope and TNF-c have in contributing to risk for RA. These studies provide additional evidence that the association of HLA alleles in RA patients from multiplex families is similar to that observed in sporadic disease, suggest candidate regions for further analysis and find additional support for an association of TNF-c alleles with RA susceptibility.

Duke Scholars

Published In

Genes Immun

DOI

ISSN

1466-4879

Publication Date

September 1999

Volume

1

Issue

1

Start / End Page

28 / 36

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Receptors, Antigen, T-Cell, alpha-beta
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • HLA Antigens
  • Genetic Markers
  • Genetic Linkage
  • Female
 

Citation

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Bali, D., Gourley, S., Kostyu, D. D., Goel, N., Bruce, I., Bell, A., … Seldin, M. F. (1999). Genetic analysis of multiplex rheumatoid arthritis families. Genes Immun, 1(1), 28–36. https://doi.org/10.1038/sj.gene.6363635
Bali, D., S. Gourley, D. D. Kostyu, N. Goel, I. Bruce, A. Bell, D. J. Walker, et al. “Genetic analysis of multiplex rheumatoid arthritis families.Genes Immun 1, no. 1 (September 1999): 28–36. https://doi.org/10.1038/sj.gene.6363635.
Bali D, Gourley S, Kostyu DD, Goel N, Bruce I, Bell A, et al. Genetic analysis of multiplex rheumatoid arthritis families. Genes Immun. 1999 Sep;1(1):28–36.
Bali, D., et al. “Genetic analysis of multiplex rheumatoid arthritis families.Genes Immun, vol. 1, no. 1, Sept. 1999, pp. 28–36. Pubmed, doi:10.1038/sj.gene.6363635.
Bali D, Gourley S, Kostyu DD, Goel N, Bruce I, Bell A, Walker DJ, Tran K, Zhu DK, Costello TJ, Amos CI, Seldin MF. Genetic analysis of multiplex rheumatoid arthritis families. Genes Immun. 1999 Sep;1(1):28–36.

Published In

Genes Immun

DOI

ISSN

1466-4879

Publication Date

September 1999

Volume

1

Issue

1

Start / End Page

28 / 36

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Receptors, Antigen, T-Cell, alpha-beta
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • HLA Antigens
  • Genetic Markers
  • Genetic Linkage
  • Female