T cells as a self-referential, sensory organ.
Publication
, Journal Article
Davis, MM; Krogsgaard, M; Huse, M; Huppa, J; Lillemeier, BF; Li, Q-J
Published in: Annu Rev Immunol
2007
In light of recent data showing that both helper and cytotoxic T cells can detect even a single molecule of an agonist peptide-MHC, alphabeta T cells are clearly a type of sensory cell, comparable to any in the nervous system. In addition, endogenous (self) peptides bound to MHCs are not just important for thymic selection, but also play an integral role in T cell activation in the response to foreign antigens. With the multitude of specificities available to most T cells, they can thus be considered as a sensory organ, trained on self-peptide-MHCs and primed to detect nonself.
Duke Scholars
Published In
Annu Rev Immunol
DOI
ISSN
0732-0582
Publication Date
2007
Volume
25
Start / End Page
681 / 695
Location
United States
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Receptors, Antigen, T-Cell, alpha-beta
- Peptides
- Lymphocyte Activation
- Immunology
- Humans
- Histocompatibility Antigens
- Autoimmunity
- Antigens
Citation
APA
Chicago
ICMJE
MLA
NLM
Davis, M. M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B. F., & Li, Q.-J. (2007). T cells as a self-referential, sensory organ. Annu Rev Immunol, 25, 681–695. https://doi.org/10.1146/annurev.immunol.24.021605.090600
Davis, Mark M., Michelle Krogsgaard, Morgan Huse, Johannes Huppa, Bjoern F. Lillemeier, and Qi-jing Li. “T cells as a self-referential, sensory organ.” Annu Rev Immunol 25 (2007): 681–95. https://doi.org/10.1146/annurev.immunol.24.021605.090600.
Davis MM, Krogsgaard M, Huse M, Huppa J, Lillemeier BF, Li Q-J. T cells as a self-referential, sensory organ. Annu Rev Immunol. 2007;25:681–95.
Davis, Mark M., et al. “T cells as a self-referential, sensory organ.” Annu Rev Immunol, vol. 25, 2007, pp. 681–95. Pubmed, doi:10.1146/annurev.immunol.24.021605.090600.
Davis MM, Krogsgaard M, Huse M, Huppa J, Lillemeier BF, Li Q-J. T cells as a self-referential, sensory organ. Annu Rev Immunol. 2007;25:681–695.
Published In
Annu Rev Immunol
DOI
ISSN
0732-0582
Publication Date
2007
Volume
25
Start / End Page
681 / 695
Location
United States
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Receptors, Antigen, T-Cell, alpha-beta
- Peptides
- Lymphocyte Activation
- Immunology
- Humans
- Histocompatibility Antigens
- Autoimmunity
- Antigens