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Childhood vaccine development: an overview.

Publication ,  Journal Article
Baker, JP; Katz, SL
Published in: Pediatr Res
February 2004

Vaccines against childhood diseases represent some of the most important applications of 20th-century pediatric research. This survey examines how the components of the current U.S. immunization schedule emerged in three phases during the course of the century. The first phase, after the development of bacterial culture techniques, witnessed numerous efforts in the early 1900s to develop bacterial vaccines. It proved most fruitful with respect to diphtheria, tetanus, and pertussis. The rise of viral tissue culture techniques in the 1950s brought about a second phase of innovation resulting in vaccines against polio, measles, mumps, rubella, and varicella. A third wave of innovation, still very much alive, has drawn on a variety of new technologies and led to vaccines against hepatitis B, Haemophilus influenzae type b, pneumococcus, and still other organisms. Although basic science research has thus been a primary factor shaping the history of vaccine development, the collaboration between the academic, private, and public sectors critical to its application has not always proceeded smoothly. The history of vaccine research and development has important implications for today, as a variety of factors threaten to fragment this network.

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Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

February 2004

Volume

55

Issue

2

Start / End Page

347 / 356

Location

United States

Related Subject Headings

  • Viral Vaccines
  • Vaccination
  • Pediatrics
  • Humans
  • History, 21st Century
  • History, 20th Century
  • Communicable Diseases
  • Communicable Disease Control
  • Child
  • Bacterial Vaccines
 

Citation

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Baker, J. P., & Katz, S. L. (2004). Childhood vaccine development: an overview. Pediatr Res, 55(2), 347–356. https://doi.org/10.1203/01.PDR.0000106317.36875.6A
Baker, Jeffrey P., and Samuel L. Katz. “Childhood vaccine development: an overview.Pediatr Res 55, no. 2 (February 2004): 347–56. https://doi.org/10.1203/01.PDR.0000106317.36875.6A.
Baker JP, Katz SL. Childhood vaccine development: an overview. Pediatr Res. 2004 Feb;55(2):347–56.
Baker, Jeffrey P., and Samuel L. Katz. “Childhood vaccine development: an overview.Pediatr Res, vol. 55, no. 2, Feb. 2004, pp. 347–56. Pubmed, doi:10.1203/01.PDR.0000106317.36875.6A.
Baker JP, Katz SL. Childhood vaccine development: an overview. Pediatr Res. 2004 Feb;55(2):347–356.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

February 2004

Volume

55

Issue

2

Start / End Page

347 / 356

Location

United States

Related Subject Headings

  • Viral Vaccines
  • Vaccination
  • Pediatrics
  • Humans
  • History, 21st Century
  • History, 20th Century
  • Communicable Diseases
  • Communicable Disease Control
  • Child
  • Bacterial Vaccines