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Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.

Publication ,  Journal Article
Yin, HH; Adermark, L; Lovinger, DM
Published in: Neuropharmacology
January 2008

Neurotensin is a peptide that has been suggested to mimic the actions of antipsychotics, but little is known about how it affects synaptic transmission in the striatum, the major input nucleus of the basal ganglia. In this study we measured the effects of neurotensin on EPSCs from medium spiny projection neurons in the sensorimotor striatum, a region implicated in habit formation and control of motor sequences. We found that bath-applied neurotensin reduced glutamate release from presynaptic terminals, and that this effect required retrograde endocannabinoid signaling, as it was prevented by the CB1 cannabinoid receptor antagonist AM251. Neurotensin-mediated inhibition of striatal EPSCs was also blocked by antagonists of D2-like dopamine receptors and group I metabotropic glutamate receptors, as well as by intracellular calcium chelation and phospholipase C inhibition. These results suggest that neurotensin can indirectly engage an endocannabinoid-mediated negative feedback signal to control glutamatergic input to the basal ganglia.

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Published In

Neuropharmacology

DOI

EISSN

1873-7064

ISSN

0028-3908

Publication Date

January 2008

Volume

54

Issue

1

Start / End Page

79 / 86

Related Subject Headings

  • Signal Transduction
  • Rats, Sprague-Dawley
  • Rats
  • Quinolines
  • Pyrazoles
  • Piperidines
  • Patch-Clamp Techniques
  • Neurotensin
  • Neurons
  • Neurology & Neurosurgery
 

Citation

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Yin, H. H., Adermark, L., & Lovinger, D. M. (2008). Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology, 54(1), 79–86. https://doi.org/10.1016/j.neuropharm.2007.06.004
Yin, Henry H., Louise Adermark, and David M. Lovinger. “Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.Neuropharmacology 54, no. 1 (January 2008): 79–86. https://doi.org/10.1016/j.neuropharm.2007.06.004.
Yin, Henry H., et al. “Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.Neuropharmacology, vol. 54, no. 1, Jan. 2008, pp. 79–86. Epmc, doi:10.1016/j.neuropharm.2007.06.004.
Journal cover image

Published In

Neuropharmacology

DOI

EISSN

1873-7064

ISSN

0028-3908

Publication Date

January 2008

Volume

54

Issue

1

Start / End Page

79 / 86

Related Subject Headings

  • Signal Transduction
  • Rats, Sprague-Dawley
  • Rats
  • Quinolines
  • Pyrazoles
  • Piperidines
  • Patch-Clamp Techniques
  • Neurotensin
  • Neurons
  • Neurology & Neurosurgery