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Rheological properties of contraceptive gels.

Publication ,  Journal Article
Owen, DH; Peters, JJ; Katz, DF
Published in: Contraception
December 2000

The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II, and Advantage-S included stress growth, stress relaxation and residual stress, and the shear rate dependence of viscosity. All gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity. Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant.

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Published In

Contraception

DOI

EISSN

1879-0518

ISSN

0010-7824

Publication Date

December 2000

Volume

62

Issue

6

Start / End Page

321 / 326

Related Subject Headings

  • Vagina
  • Spermatocidal Agents
  • Rheology
  • Obstetrics & Reproductive Medicine
  • Humans
  • Gels
  • Female
  • Chemistry, Pharmaceutical
  • Carboxymethylcellulose Sodium
  • Body Fluids
 

Citation

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Owen, D. H., Peters, J. J., & Katz, D. F. (2000). Rheological properties of contraceptive gels. Contraception, 62(6), 321–326. https://doi.org/10.1016/s0010-7824(00)00184-0
Owen, D. H., J. J. Peters, and D. F. Katz. “Rheological properties of contraceptive gels.Contraception 62, no. 6 (December 2000): 321–26. https://doi.org/10.1016/s0010-7824(00)00184-0.
Owen DH, Peters JJ, Katz DF. Rheological properties of contraceptive gels. Contraception. 2000 Dec;62(6):321–6.
Owen, D. H., et al. “Rheological properties of contraceptive gels.Contraception, vol. 62, no. 6, Dec. 2000, pp. 321–26. Epmc, doi:10.1016/s0010-7824(00)00184-0.
Owen DH, Peters JJ, Katz DF. Rheological properties of contraceptive gels. Contraception. 2000 Dec;62(6):321–326.
Journal cover image

Published In

Contraception

DOI

EISSN

1879-0518

ISSN

0010-7824

Publication Date

December 2000

Volume

62

Issue

6

Start / End Page

321 / 326

Related Subject Headings

  • Vagina
  • Spermatocidal Agents
  • Rheology
  • Obstetrics & Reproductive Medicine
  • Humans
  • Gels
  • Female
  • Chemistry, Pharmaceutical
  • Carboxymethylcellulose Sodium
  • Body Fluids