Skip to main content
Journal cover image

Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors.

Publication ,  Journal Article
Arumugam, R; Fleenor, D; Freemark, M
Published in: Endocrine
October 2007

We recently described a novel mouse model that combines resistance to lactogenic hormones with GH deficiency (GHD). The GHD/lactogen-resistant males develop obesity and insulin resistance with age. We hypothesized that altered production of pancreatic hormones and dysregulation of adipocytokine secretion and action contribute to the pathogenesis of their insulin resistance. Double-mutant males (age 12-16 months) had fasting hyperinsulinemia, hyperamylinemia, hyperleptinemia, and a decreased ratio of adiponectin to leptin. Adiponectin receptor 1 and 2 (AdipoR1 and R2) mRNA levels in liver and skeletal muscle were normal but hepatic insulin receptor mRNA was increased. Relative to double-mutant males, GHD males had lower levels of insulin, amylin, and leptin, higher levels of adiponectin, and higher expression of hepatic AdipoR1 and insulin receptor mRNAs. Lactogen-resistant mice had reduced hepatic adipoR2 mRNA. In response to stress the plasma concentrations of MCP-1 and IL-6 increased in double-mutant males but not GHD or lactogen-resistant males. Our findings suggest that the insulin resistance of GHD/lactogen-resistant males is accompanied by dysregulation of pancreatic hormone and adipocytokine secretion and receptor expression. Phenotypic differences between double-mutant and GHD males suggest that lactogens and GH exert differential but overlapping effects on fat deposition and adipocytokine secretion and action.

Duke Scholars

Published In

Endocrine

DOI

ISSN

1355-008X

Publication Date

October 2007

Volume

32

Issue

2

Start / End Page

182 / 191

Location

United States

Related Subject Headings

  • Receptors, Adiponectin
  • Receptor, Insulin
  • Prolactin
  • Pancreatic Hormones
  • Obesity
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Leptin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Arumugam, R., Fleenor, D., & Freemark, M. (2007). Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. Endocrine, 32(2), 182–191. https://doi.org/10.1007/s12020-007-9017-y
Arumugam, Ramamani, Don Fleenor, and Michael Freemark. “Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors.Endocrine 32, no. 2 (October 2007): 182–91. https://doi.org/10.1007/s12020-007-9017-y.
Arumugam, Ramamani, et al. “Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors.Endocrine, vol. 32, no. 2, Oct. 2007, pp. 182–91. Pubmed, doi:10.1007/s12020-007-9017-y.
Journal cover image

Published In

Endocrine

DOI

ISSN

1355-008X

Publication Date

October 2007

Volume

32

Issue

2

Start / End Page

182 / 191

Location

United States

Related Subject Headings

  • Receptors, Adiponectin
  • Receptor, Insulin
  • Prolactin
  • Pancreatic Hormones
  • Obesity
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Leptin