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Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.

Publication ,  Journal Article
Rubnitz, JE; Wichlan, D; Devidas, M; Shuster, J; Linda, SB; Kurtzberg, J; Bell, B; Hunger, SP; Chauvenet, A; Pui, C-H; Camitta, B; Pullen, J ...
Published in: J Clin Oncol
May 1, 2008

PURPOSE: To prospectively determine the prognostic significance of the TEL-AML1 fusion in children with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: TEL gene status was determined for 926 patients with B-precursor ALL enrolled on the Pediatric Oncology Group ALinC 16 trials and patients were observed for a median time of 8 years. RESULTS: Rearrangements of the TEL gene were detected in 244 patients (26%). The estimated 5-year event-free survival rate (+/- SE) for patients with TEL rearrangements was 86% +/- 2%, compared with 72% +/- 2% for those with germline TEL (P < .0001). TEL rearrangements were associated with a superior outcome among patients with standard-risk ALL, high-risk ALL, and rapid early responses to therapy. In a multivariate analysis that included risk group, sex, and day 15 marrow status, TEL status was an independent predictor of outcome (P = .0002). CONCLUSION: We conclude that TEL gene status should be incorporated into risk classification schemes and suggest that patients who have standard-risk features, the TEL-AML1 fusion, and rapid early responses to therapy, should be treated with antimetabolite-based therapy designed to maintain their high cure rates and avoid late effects.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

May 1, 2008

Volume

26

Issue

13

Start / End Page

2186 / 2191

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Sex Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
 

Citation

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Rubnitz, J. E., Wichlan, D., Devidas, M., Shuster, J., Linda, S. B., Kurtzberg, J., … Children’s Oncology Group, . (2008). Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study. J Clin Oncol, 26(13), 2186–2191. https://doi.org/10.1200/JCO.2007.14.3552
Rubnitz, Jeffrey E., David Wichlan, Meenakshi Devidas, Jonathan Shuster, Stephen B. Linda, Joanne Kurtzberg, Beverly Bell, et al. “Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.J Clin Oncol 26, no. 13 (May 1, 2008): 2186–91. https://doi.org/10.1200/JCO.2007.14.3552.
Rubnitz JE, Wichlan D, Devidas M, Shuster J, Linda SB, Kurtzberg J, et al. Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study. J Clin Oncol. 2008 May 1;26(13):2186–91.
Rubnitz, Jeffrey E., et al. “Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.J Clin Oncol, vol. 26, no. 13, May 2008, pp. 2186–91. Pubmed, doi:10.1200/JCO.2007.14.3552.
Rubnitz JE, Wichlan D, Devidas M, Shuster J, Linda SB, Kurtzberg J, Bell B, Hunger SP, Chauvenet A, Pui C-H, Camitta B, Pullen J, Children’s Oncology Group. Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study. J Clin Oncol. 2008 May 1;26(13):2186–2191.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

May 1, 2008

Volume

26

Issue

13

Start / End Page

2186 / 2191

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Sex Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma