Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.
Publication
, Journal Article
Bö, L; Dawson, TM; Wesselingh, S; Mörk, S; Choi, S; Kong, PA; Hanley, D; Trapp, BD
Published in: Ann Neurol
November 1994
The amount of messenger RNA encoding human inducible nitric oxide synthase and the presence and distribution of NADPH diaphorase were determined in tissue sections from multiple sclerosis (MS) and control brains. Levels of human nitric oxide synthase messenger RNA were markedly elevated in MS brains when compared to normal control brains. NADPH diaphorase activity, a histochemical stain reflecting nitric oxide synthase catalytic activity, was detected in reactive astrocytes in active demyelinating MS lesions and at the edge of chronic active demyelinating lesions. Control brains did not contain NADPH diaphorase-positive astrocytes. These results implicate the free radical nitric oxide in the pathogenesis of demyelinating MS lesions.
Duke Scholars
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Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
November 1994
Volume
36
Issue
5
Start / End Page
778 / 786
Location
United States
Related Subject Headings
- Nitric Oxide Synthase
- Neurology & Neurosurgery
- NADPH Dehydrogenase
- Multiple Sclerosis
- Molecular Sequence Data
- Middle Aged
- Immunoenzyme Techniques
- Humans
- Enzyme Induction
- Brain
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APA
Chicago
ICMJE
MLA
NLM
Bö, L., Dawson, T. M., Wesselingh, S., Mörk, S., Choi, S., Kong, P. A., … Trapp, B. D. (1994). Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol, 36(5), 778–786. https://doi.org/10.1002/ana.410360515
Bö, L., T. M. Dawson, S. Wesselingh, S. Mörk, S. Choi, P. A. Kong, D. Hanley, and B. D. Trapp. “Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.” Ann Neurol 36, no. 5 (November 1994): 778–86. https://doi.org/10.1002/ana.410360515.
Bö L, Dawson TM, Wesselingh S, Mörk S, Choi S, Kong PA, et al. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol. 1994 Nov;36(5):778–86.
Bö, L., et al. “Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.” Ann Neurol, vol. 36, no. 5, Nov. 1994, pp. 778–86. Pubmed, doi:10.1002/ana.410360515.
Bö L, Dawson TM, Wesselingh S, Mörk S, Choi S, Kong PA, Hanley D, Trapp BD. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol. 1994 Nov;36(5):778–786.
Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
November 1994
Volume
36
Issue
5
Start / End Page
778 / 786
Location
United States
Related Subject Headings
- Nitric Oxide Synthase
- Neurology & Neurosurgery
- NADPH Dehydrogenase
- Multiple Sclerosis
- Molecular Sequence Data
- Middle Aged
- Immunoenzyme Techniques
- Humans
- Enzyme Induction
- Brain