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African-American HLA class II allele and haplotype diversity.

Publication ,  Journal Article
Just, JJ; King, MC; Thomson, G; Klitz, W
Published in: Tissue Antigens
May 1997

Molecular genetic techniques were used to type nine loci in the HLA class II region in 241 unrelated African-Americans from New York City (NYC). Several effects attributable to recent genetic admixture were evident: the number of distinct class II alleles and haplotypes was larger in the African-Americans than in people of African or European origin, the allele frequencies were more consistently even, and linkage disequilibrium was present across the entire class II region. The African-American DRB1 allele frequencies almost always fell between frequencies among samples from northern Europe and the Gambia, two possible founding populations. The exceptions are attributed to the contribution of other genetically dissimilar African groups to the African-American gene pool. DRB1 allele frequencies (specifically DRB1*1501) and some haplotypes of DRB1-DPB1 were different in our NYC and the 11th International Histocompatibility Workshop (IHW) samples of African-Americans. The high level of allele and haplotype diversity found in African-Americans has important implications for the construction of pools of unrelated potential donors for tissue transplantation.

Duke Scholars

Published In

Tissue Antigens

DOI

ISSN

0001-2815

Publication Date

May 1997

Volume

49

Issue

5

Start / End Page

547 / 555

Location

England

Related Subject Headings

  • Polymorphism, Genetic
  • Immunology
  • Humans
  • Histocompatibility Antigens Class II
  • Haplotypes
  • Genetic Variation
  • Gene Frequency
  • Black People
  • Alleles
  • 3204 Immunology
 

Citation

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ICMJE
MLA
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Just, J. J., King, M. C., Thomson, G., & Klitz, W. (1997). African-American HLA class II allele and haplotype diversity. Tissue Antigens, 49(5), 547–555. https://doi.org/10.1111/j.1399-0039.1997.tb02801.x
Just, J. J., M. C. King, G. Thomson, and W. Klitz. “African-American HLA class II allele and haplotype diversity.Tissue Antigens 49, no. 5 (May 1997): 547–55. https://doi.org/10.1111/j.1399-0039.1997.tb02801.x.
Just JJ, King MC, Thomson G, Klitz W. African-American HLA class II allele and haplotype diversity. Tissue Antigens. 1997 May;49(5):547–55.
Just, J. J., et al. “African-American HLA class II allele and haplotype diversity.Tissue Antigens, vol. 49, no. 5, May 1997, pp. 547–55. Pubmed, doi:10.1111/j.1399-0039.1997.tb02801.x.
Just JJ, King MC, Thomson G, Klitz W. African-American HLA class II allele and haplotype diversity. Tissue Antigens. 1997 May;49(5):547–555.
Journal cover image

Published In

Tissue Antigens

DOI

ISSN

0001-2815

Publication Date

May 1997

Volume

49

Issue

5

Start / End Page

547 / 555

Location

England

Related Subject Headings

  • Polymorphism, Genetic
  • Immunology
  • Humans
  • Histocompatibility Antigens Class II
  • Haplotypes
  • Genetic Variation
  • Gene Frequency
  • Black People
  • Alleles
  • 3204 Immunology