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Taking cardiovascular genetic association studies to the next level.

Publication ,  Journal Article
Ginsburg, GS; Shah, SH; McCarthy, JJ
Published in: J Am Coll Cardiol
September 4, 2007

Genetic information is beginning to have a direct impact on patient care and it is important that cardiologists appreciate the value and approaches to associating genetic variation and health outcomes. Genetic associations should be based on compelling genetic and biological hypotheses and should be statistically sound so as to reduce the possibility of "false discovery" in the setting of testing multiple hypotheses. Study designs should clearly define cases and controls and measurement of phenotypes. Finally, findings should be replicated in at least 1 independent cohort. Consideration of these principles should provide insight into disease biology based on genetic findings and encourage their meaningful adoption into clinical practice.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

September 4, 2007

Volume

50

Issue

10

Start / End Page

930 / 932

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Phenotype
  • Linkage Disequilibrium
  • Humans
  • Genotype
  • Genetic Variation
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Cardiology
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
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ICMJE
MLA
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Ginsburg, G. S., Shah, S. H., & McCarthy, J. J. (2007). Taking cardiovascular genetic association studies to the next level. J Am Coll Cardiol, 50(10), 930–932. https://doi.org/10.1016/j.jacc.2007.05.025
Ginsburg, Geoffrey S., Svati H. Shah, and Jeanette J. McCarthy. “Taking cardiovascular genetic association studies to the next level.J Am Coll Cardiol 50, no. 10 (September 4, 2007): 930–32. https://doi.org/10.1016/j.jacc.2007.05.025.
Ginsburg GS, Shah SH, McCarthy JJ. Taking cardiovascular genetic association studies to the next level. J Am Coll Cardiol. 2007 Sep 4;50(10):930–2.
Ginsburg, Geoffrey S., et al. “Taking cardiovascular genetic association studies to the next level.J Am Coll Cardiol, vol. 50, no. 10, Sept. 2007, pp. 930–32. Pubmed, doi:10.1016/j.jacc.2007.05.025.
Ginsburg GS, Shah SH, McCarthy JJ. Taking cardiovascular genetic association studies to the next level. J Am Coll Cardiol. 2007 Sep 4;50(10):930–932.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

September 4, 2007

Volume

50

Issue

10

Start / End Page

930 / 932

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Phenotype
  • Linkage Disequilibrium
  • Humans
  • Genotype
  • Genetic Variation
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Cardiology
  • 3201 Cardiovascular medicine and haematology