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Neural signatures of economic preferences for risk and ambiguity.

Publication ,  Journal Article
Huettel, SA; Stowe, CJ; Gordon, EM; Warner, BT; Platt, ML
Published in: Neuron
March 2, 2006

People often prefer the known over the unknown, sometimes sacrificing potential rewards for the sake of surety. Overcoming impulsive preferences for certainty in order to exploit uncertain but potentially lucrative options may require specialized neural mechanisms. Here, we demonstrate by functional magnetic resonance imaging (fMRI) that individuals' preferences for risk (uncertainty with known probabilities) and ambiguity (uncertainty with unknown probabilities) predict brain activation associated with decision making. Activation within the lateral prefrontal cortex was predicted by ambiguity preference and was also negatively correlated with an independent clinical measure of behavioral impulsiveness, suggesting that this region implements contextual analysis and inhibits impulsive responses. In contrast, activation of the posterior parietal cortex was predicted by risk preference. Together, this novel double dissociation indicates that decision making under ambiguity does not represent a special, more complex case of risky decision making; instead, these two forms of uncertainty are supported by distinct mechanisms.

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Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

March 2, 2006

Volume

49

Issue

5

Start / End Page

765 / 775

Location

United States

Related Subject Headings

  • Visual Perception
  • Uncertainty
  • Statistics as Topic
  • Risk-Taking
  • Reward
  • Reaction Time
  • Photic Stimulation
  • Oxygen
  • Neurology & Neurosurgery
  • Mental Processes
 

Citation

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Huettel, S. A., Stowe, C. J., Gordon, E. M., Warner, B. T., & Platt, M. L. (2006). Neural signatures of economic preferences for risk and ambiguity. Neuron, 49(5), 765–775. https://doi.org/10.1016/j.neuron.2006.01.024
Huettel, Scott A., C Jill Stowe, Evan M. Gordon, Brent T. Warner, and Michael L. Platt. “Neural signatures of economic preferences for risk and ambiguity.Neuron 49, no. 5 (March 2, 2006): 765–75. https://doi.org/10.1016/j.neuron.2006.01.024.
Huettel SA, Stowe CJ, Gordon EM, Warner BT, Platt ML. Neural signatures of economic preferences for risk and ambiguity. Neuron. 2006 Mar 2;49(5):765–75.
Huettel, Scott A., et al. “Neural signatures of economic preferences for risk and ambiguity.Neuron, vol. 49, no. 5, Mar. 2006, pp. 765–75. Pubmed, doi:10.1016/j.neuron.2006.01.024.
Huettel SA, Stowe CJ, Gordon EM, Warner BT, Platt ML. Neural signatures of economic preferences for risk and ambiguity. Neuron. 2006 Mar 2;49(5):765–775.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

March 2, 2006

Volume

49

Issue

5

Start / End Page

765 / 775

Location

United States

Related Subject Headings

  • Visual Perception
  • Uncertainty
  • Statistics as Topic
  • Risk-Taking
  • Reward
  • Reaction Time
  • Photic Stimulation
  • Oxygen
  • Neurology & Neurosurgery
  • Mental Processes