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Comparison of short bowel syndrome acquired early in life and during adolescence.

Publication ,  Journal Article
Bruzoni, M; Sudan, DL; Cusick, RA; Thompson, JS
Published in: Transplantation
July 15, 2008

BACKGROUND: Prolonged survival in pediatric patients with short bowel syndrome (SBS) is now possible because of parenteral nutrition and small bowel transplantation. We hypothesized that there may be important differences between adult patients who developed SBS during early childhood and those who develop this as adolescents. METHODS: Sixty-seven patients between the ages of 16 and 40 years were studied. Thirty patients developing SBS younger than 12 years comprised the pediatric group (PG), 37 developing SBS at age 13 to 25 constituted the adolescent group (AG). RESULTS: Midgut volvulus (n=11) was the most common cause in the PG followed by gastroschisis (n=5), intestinal atresia (n=5), and necrotizing enterocolitis (n=4). The most common cause of SBS in the AG was trauma (n=13), followed by tumors (n=7) and postoperative complications (n=5). A similar portion in each group had intestinal remnants less than 60 cm (69% vs. 58%), however, the PG was more likely to have a colon remnant (97% vs. 71%, P<0.05), and less likely to have an ostomy (7% vs. 47%, P<0.05). Patients in PG were followed significantly longer than AG (246+/-67 vs. 90+/-58 months, P<0.05). A similar portion of the patients require long-term parenteral nutrition (86% vs. 84%) or have undergone intestinal transplant (28% vs. 23%). Significantly more pediatric patients had negative height z scores when compared with the adolescents. CONCLUSIONS: Acknowledging the inherent biases created in defining the two groups, pediatric patients developing SBS early in life seem to be similar to those who develop SBS as adolescents with regards to long-term outcome, despite differences in origin and intestinal anatomy.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 15, 2008

Volume

86

Issue

1

Start / End Page

63 / 66

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Treatment Outcome
  • Surgery
  • Short Bowel Syndrome
  • Risk Factors
  • Retrospective Studies
  • Parenteral Nutrition
  • Neoplasms
  • Intestines
  • Intestinal Volvulus
 

Citation

APA
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MLA
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Bruzoni, M., Sudan, D. L., Cusick, R. A., & Thompson, J. S. (2008). Comparison of short bowel syndrome acquired early in life and during adolescence. Transplantation, 86(1), 63–66. https://doi.org/10.1097/TP.0b013e3181734995
Bruzoni, Matias, Debra L. Sudan, Robert A. Cusick, and Jon S. Thompson. “Comparison of short bowel syndrome acquired early in life and during adolescence.Transplantation 86, no. 1 (July 15, 2008): 63–66. https://doi.org/10.1097/TP.0b013e3181734995.
Bruzoni M, Sudan DL, Cusick RA, Thompson JS. Comparison of short bowel syndrome acquired early in life and during adolescence. Transplantation. 2008 Jul 15;86(1):63–6.
Bruzoni, Matias, et al. “Comparison of short bowel syndrome acquired early in life and during adolescence.Transplantation, vol. 86, no. 1, July 2008, pp. 63–66. Pubmed, doi:10.1097/TP.0b013e3181734995.
Bruzoni M, Sudan DL, Cusick RA, Thompson JS. Comparison of short bowel syndrome acquired early in life and during adolescence. Transplantation. 2008 Jul 15;86(1):63–66.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 15, 2008

Volume

86

Issue

1

Start / End Page

63 / 66

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Treatment Outcome
  • Surgery
  • Short Bowel Syndrome
  • Risk Factors
  • Retrospective Studies
  • Parenteral Nutrition
  • Neoplasms
  • Intestines
  • Intestinal Volvulus