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Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation.

Publication ,  Journal Article
Cauble, MS; Gilroy, R; Sorrell, MF; Mailliard, ME; Sudan, DL; Anderson, JC; Wisecarver, JL; Balakrishnan, S; Larsen, JL
Published in: Transplantation
April 15, 2001

BACKGROUND: Lipoatrophic diabetes is an insulin resistance syndrome characterized by the complete or partial lack of adipose tissue and disturbances in lipid and glucose metabolism. Nonalcoholic steatohepatitis (NASH) is a well-described change in liver pathology consisting of steatosis, hepatitis, and fibrosis that can be associated with lipoatrophic diabetes. RESULTS: This article describes the first reported case of lipoatrophic diabetes with NASH leading to liver failure and liver transplantation. Before transplantation, the patient required 600-700 U of insulin/day. After transplantation, a dramatic decline in her insulin requirements was observed, despite corticosteroids. Eighteen months after transplantation, her glycemic control worsened, and she developed recurrent NASH on serial liver biopsies. CONCLUSIONS: NASH associated with lipoatrophic diabetes can recur after liver transplantation, and in this case, was accompanied by increased insulin requirements. These results suggest that the development of NASH itself may contribute to the insulin resistance observed in lipoatrophic diabetes.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

April 15, 2001

Volume

71

Issue

7

Start / End Page

892 / 895

Location

United States

Related Subject Headings

  • Surgery
  • Recurrence
  • Liver Transplantation
  • Liver Failure
  • Liver Cirrhosis
  • Liver
  • Insulin Resistance
  • Humans
  • Hepatitis
  • Female
 

Citation

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Cauble, M. S., Gilroy, R., Sorrell, M. F., Mailliard, M. E., Sudan, D. L., Anderson, J. C., … Larsen, J. L. (2001). Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation. Transplantation, 71(7), 892–895. https://doi.org/10.1097/00007890-200104150-00012
Cauble, M. S., R. Gilroy, M. F. Sorrell, M. E. Mailliard, D. L. Sudan, J. C. Anderson, J. L. Wisecarver, S. Balakrishnan, and J. L. Larsen. “Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation.Transplantation 71, no. 7 (April 15, 2001): 892–95. https://doi.org/10.1097/00007890-200104150-00012.
Cauble MS, Gilroy R, Sorrell MF, Mailliard ME, Sudan DL, Anderson JC, et al. Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation. Transplantation. 2001 Apr 15;71(7):892–5.
Cauble, M. S., et al. “Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation.Transplantation, vol. 71, no. 7, Apr. 2001, pp. 892–95. Pubmed, doi:10.1097/00007890-200104150-00012.
Cauble MS, Gilroy R, Sorrell MF, Mailliard ME, Sudan DL, Anderson JC, Wisecarver JL, Balakrishnan S, Larsen JL. Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation. Transplantation. 2001 Apr 15;71(7):892–895.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

April 15, 2001

Volume

71

Issue

7

Start / End Page

892 / 895

Location

United States

Related Subject Headings

  • Surgery
  • Recurrence
  • Liver Transplantation
  • Liver Failure
  • Liver Cirrhosis
  • Liver
  • Insulin Resistance
  • Humans
  • Hepatitis
  • Female