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Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.

Publication ,  Journal Article
Sudan, DL; Radio, SJ; Matamoros, A; Johnson, ND; Shearon, CC; Glogowski, KR; Hill, AC; Goertzen, TC; Fox, IJ; Langnas, AN; Beschorner, WE
Published in: Transplantation
January 27, 2000

BACKGROUND: Organ xenografts are fulminantly rejected by antibody-mediated vascular rejection. Surrogate tolerogenesis (ST), the induction of tolerance within the donor, is effective with aorta xenografts. This preliminary study assesses the effect of ST on preformed antibodies and rejection of porcine heart xenografts. METHODS: Tolerance to the donor pig was induced by infusing recipient marrow into fetal pigs. Later, pig splenocytes were transfused and heterotopic pig hearts transplanted using chimeric or nonchimeric pigs. Anti-pig antibodies were assessed. RESULTS: With ST alone, xenografts developed cellular rejection at 4-6 days, whereas control grafts developed vascular rejection at 3-4 days (cellular vs. vascular, P<0.03). There was a reduction in preformed antibodies (P<0.03). ST combined with moderate cyclosporine prevented rejection at 9+ and 25 days in sensitized recipients compared with vascular rejection at 0.5-2 days for controls (P<0.07). CONCLUSIONS: ST seems to provide protection against vascular rejection. The cellular rejection seems sensitive to cyclosporine.

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Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

January 27, 2000

Volume

69

Issue

2

Start / End Page

232 / 235

Location

United States

Related Subject Headings

  • Transplantation Chimera
  • Tissue Donors
  • Swine
  • Surgery
  • Spleen
  • Sheep
  • Pregnancy
  • Male
  • Immunosuppressive Agents
  • Heart Transplantation
 

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Sudan, D. L., Radio, S. J., Matamoros, A., Johnson, N. D., Shearon, C. C., Glogowski, K. R., … Beschorner, W. E. (2000). Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts. Transplantation, 69(2), 232–235. https://doi.org/10.1097/00007890-200001270-00007
Sudan, D. L., S. J. Radio, A. Matamoros, N. D. Johnson, C. C. Shearon, K. R. Glogowski, A. C. Hill, et al. “Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.Transplantation 69, no. 2 (January 27, 2000): 232–35. https://doi.org/10.1097/00007890-200001270-00007.
Sudan DL, Radio SJ, Matamoros A, Johnson ND, Shearon CC, Glogowski KR, et al. Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts. Transplantation. 2000 Jan 27;69(2):232–5.
Sudan, D. L., et al. “Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.Transplantation, vol. 69, no. 2, Jan. 2000, pp. 232–35. Pubmed, doi:10.1097/00007890-200001270-00007.
Sudan DL, Radio SJ, Matamoros A, Johnson ND, Shearon CC, Glogowski KR, Hill AC, Goertzen TC, Fox IJ, Langnas AN, Beschorner WE. Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts. Transplantation. 2000 Jan 27;69(2):232–235.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

January 27, 2000

Volume

69

Issue

2

Start / End Page

232 / 235

Location

United States

Related Subject Headings

  • Transplantation Chimera
  • Tissue Donors
  • Swine
  • Surgery
  • Spleen
  • Sheep
  • Pregnancy
  • Male
  • Immunosuppressive Agents
  • Heart Transplantation