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Steroidogenic factor 1 plays multiple roles in endocrine development and function.

Publication ,  Journal Article
Wong, M; Ikeda, Y; Luo, X; Caron, KM; Weber, TJ; Swain, A; Schimmer, BP; Parker, KL
Published in: Recent Prog Horm Res
1997

The nuclear hormone receptor family comprises a group of structurally related transcriptional regulators that mediate the actions of diverse ligands, including steroid hormones, thyroid hormone, vitamin D, and retinoids. The nuclear receptor family also contains members for which activating ligands have not been identified-the orphan nuclear receptors. One of these orphan nuclear receptors, steroidogenic factor 1 (SF-1), has emerged as an essential regulator of steroidogenic cell function within the adrenal cortex and gonads; SF-1 also plays important roles in reproduction at all three levels of the hypothalamic-pituitary-gonadal axis. First identified as a tissue-specific regulator of the transcription of the cytochrome P450 steroid hydroxylases, considerably broader roles for SF-1 were revealed by genetic studies in mice lacking SF-1 due to targeted gene disruption. These SF-1-knockout mice had agenesis of their adrenal glands and gonads, male-to-female sex reversal of their internal and external genitalia, impaired gonadotrope function, and agenesis of the ventromedial hypothalamic nucleus. These studies delineated essential roles of SF-1 in regulating endocrine differentiation and function at multiple levels. Despite these insights into roles of SF-1, the precise mechanisms by which SF-1 exerts its multiple effects remain to be determined. This review highlights experiments that have established SF-1 as a pivotal determinant of endocrine differentiation and function and identifies areas in which additional studies are needed to expand our understanding of SF-1 action.

Duke Scholars

Published In

Recent Prog Horm Res

ISSN

0079-9963

Publication Date

1997

Volume

52

Start / End Page

167 / 182

Location

United States

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Mice, Knockout
  • Mice
  • Humans
  • Homeodomain Proteins
  • Fushi Tarazu Transcription Factors
  • Endocrinology & Metabolism
  • Endocrine Glands
 

Citation

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Wong, M., Ikeda, Y., Luo, X., Caron, K. M., Weber, T. J., Swain, A., … Parker, K. L. (1997). Steroidogenic factor 1 plays multiple roles in endocrine development and function. Recent Prog Horm Res, 52, 167–182.
Wong, M., Y. Ikeda, X. Luo, K. M. Caron, T. J. Weber, A. Swain, B. P. Schimmer, and K. L. Parker. “Steroidogenic factor 1 plays multiple roles in endocrine development and function.Recent Prog Horm Res 52 (1997): 167–82.
Wong M, Ikeda Y, Luo X, Caron KM, Weber TJ, Swain A, et al. Steroidogenic factor 1 plays multiple roles in endocrine development and function. Recent Prog Horm Res. 1997;52:167–82.
Wong, M., et al. “Steroidogenic factor 1 plays multiple roles in endocrine development and function.Recent Prog Horm Res, vol. 52, 1997, pp. 167–82.
Wong M, Ikeda Y, Luo X, Caron KM, Weber TJ, Swain A, Schimmer BP, Parker KL. Steroidogenic factor 1 plays multiple roles in endocrine development and function. Recent Prog Horm Res. 1997;52:167–182.

Published In

Recent Prog Horm Res

ISSN

0079-9963

Publication Date

1997

Volume

52

Start / End Page

167 / 182

Location

United States

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Mice, Knockout
  • Mice
  • Humans
  • Homeodomain Proteins
  • Fushi Tarazu Transcription Factors
  • Endocrinology & Metabolism
  • Endocrine Glands