Skip to main content
Journal cover image

Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.

Publication ,  Journal Article
Noor, MAF
Published in: Molecular biology and evolution
November 2008

Local rates of recombination positively correlate with DNA sequence diversity in many species. To test whether this relationship stems from mutagenicity of meiotic recombination, studies often look for a similar association between local rates of recombination and sequence "divergence" between species. Because recombination is mutagenic in yeast, I evaluate this assay by testing whether noncoding DNA sequence divergence between Saccharomyces species is related to measures of meiotic double-strand DNA breaks or crossover rates derived from Saccharomyces cerevisiae. Contrary to expectation, I find that sequence divergence is either uncorrelated or negatively correlated with rates of both double-strand break and crossover. Several caveats are mentioned, but these results suggest that mutagenesis from meiotic recombination is not the primary driver of sequence divergence between Saccharomyces species. This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity.

Duke Scholars

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

November 2008

Volume

25

Issue

11

Start / End Page

2439 / 2444

Related Subject Headings

  • Species Specificity
  • Saccharomyces cerevisiae
  • Saccharomyces
  • Recombination, Genetic
  • Mutagenesis
  • Meiosis
  • Evolutionary Biology
  • Evolution, Molecular
  • DNA, Fungal
  • DNA Breaks, Double-Stranded
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Noor, M. A. F. (2008). Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species. Molecular Biology and Evolution, 25(11), 2439–2444. https://doi.org/10.1093/molbev/msn186
Noor, Mohamed A. F. “Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.Molecular Biology and Evolution 25, no. 11 (November 2008): 2439–44. https://doi.org/10.1093/molbev/msn186.
Noor, Mohamed A. F. “Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.Molecular Biology and Evolution, vol. 25, no. 11, Nov. 2008, pp. 2439–44. Epmc, doi:10.1093/molbev/msn186.
Journal cover image

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

November 2008

Volume

25

Issue

11

Start / End Page

2439 / 2444

Related Subject Headings

  • Species Specificity
  • Saccharomyces cerevisiae
  • Saccharomyces
  • Recombination, Genetic
  • Mutagenesis
  • Meiosis
  • Evolutionary Biology
  • Evolution, Molecular
  • DNA, Fungal
  • DNA Breaks, Double-Stranded