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Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.

Publication ,  Journal Article
Matell, MS; Meck, WH; Nicolelis, MAL
Published in: Behav Neurosci
August 2003

This study investigated the firing patterns of striatal and cortical neurons in rats in a temporal generalization task. Striatal and cortical ensembles were recorded in rats trained to lever press at 2 possible criterion durations (10 s or 40 s from tone onset). Twenty-two percent of striatal and 15% of cortical cells had temporally specific modulations in their firing rate, firing at a significantly different rate around 10 s compared with 40 s. On 80% of trials, a post hoc analysis of the trial-by-trial consistency of the firing rates of an ensemble of neurons predicted whether a spike train came from a time window around 10 s versus around 40 s. Results suggest that striatal and cortical neurons encode specific durations in their firing rate and thereby serve as components of a neural circuit used to represent duration.

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Published In

Behav Neurosci

DOI

ISSN

0735-7044

Publication Date

August 2003

Volume

117

Issue

4

Start / End Page

760 / 773

Location

United States

Related Subject Headings

  • Time Perception
  • Rats, Sprague-Dawley
  • Rats
  • Neurons
  • Male
  • Discrimination Learning
  • Corpus Striatum
  • Conditioning, Operant
  • Cerebral Cortex
  • Behavioral Science & Comparative Psychology
 

Citation

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Matell, M. S., Meck, W. H., & Nicolelis, M. A. L. (2003). Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behav Neurosci, 117(4), 760–773. https://doi.org/10.1037/0735-7044.117.4.760
Matell, Matthew S., Warren H. Meck, and Miguel A. L. Nicolelis. “Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.Behav Neurosci 117, no. 4 (August 2003): 760–73. https://doi.org/10.1037/0735-7044.117.4.760.
Matell MS, Meck WH, Nicolelis MAL. Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behav Neurosci. 2003 Aug;117(4):760–73.
Matell, Matthew S., et al. “Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.Behav Neurosci, vol. 117, no. 4, Aug. 2003, pp. 760–73. Pubmed, doi:10.1037/0735-7044.117.4.760.
Matell MS, Meck WH, Nicolelis MAL. Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behav Neurosci. 2003 Aug;117(4):760–773.

Published In

Behav Neurosci

DOI

ISSN

0735-7044

Publication Date

August 2003

Volume

117

Issue

4

Start / End Page

760 / 773

Location

United States

Related Subject Headings

  • Time Perception
  • Rats, Sprague-Dawley
  • Rats
  • Neurons
  • Male
  • Discrimination Learning
  • Corpus Striatum
  • Conditioning, Operant
  • Cerebral Cortex
  • Behavioral Science & Comparative Psychology