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Age-related differences in brain activity during true and false memory retrieval.

Publication ,  Journal Article
Dennis, NA; Kim, H; Cabeza, R
Published in: Journal of cognitive neuroscience
August 2008

Compared to young adults, older adults show not only a reduction in true memories but also an increase in false memories. We investigated the neural bases of these age effects using functional magnetic resonance imaging and a false memory task that resembles the Deese-Roediger-McDermott (DRM) paradigm. Young and older participants were scanned during a word recognition task that included studied words and new words that were strongly associated with studied words (critical lures). During correct recognition of studied words (true memory), older adults showed weaker activity than young adults in the hippocampus but stronger activity than young adults in the retrosplenial cortex. The hippocampal reduction is consistent with age-related deficits in recollection, whereas the retrosplenial increase suggests compensatory recruitment of alternative recollection-related regions. During incorrect recognition of critical lures (false memory), older adults displayed stronger activity than young adults in the left lateral temporal cortex, a region involved in semantic processing and semantic gist. Taken together, the results suggest that older adults' deficits in true memories reflect a decline in recollection processes mediated by the hippocampus, whereas their increased tendency to have false memories reflects their reliance on semantic gist mediated by the lateral temporal cortex.

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Published In

Journal of cognitive neuroscience

DOI

EISSN

1530-8898

ISSN

0898-929X

Publication Date

August 2008

Volume

20

Issue

8

Start / End Page

1390 / 1402

Related Subject Headings

  • Recognition, Psychology
  • Reaction Time
  • Oxygen
  • Neuropsychological Tests
  • Middle Aged
  • Mental Recall
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
 

Citation

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ICMJE
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Dennis, N. A., Kim, H., & Cabeza, R. (2008). Age-related differences in brain activity during true and false memory retrieval. Journal of Cognitive Neuroscience, 20(8), 1390–1402. https://doi.org/10.1162/jocn.2008.20096
Dennis, Nancy A., Hongkeun Kim, and Roberto Cabeza. “Age-related differences in brain activity during true and false memory retrieval.Journal of Cognitive Neuroscience 20, no. 8 (August 2008): 1390–1402. https://doi.org/10.1162/jocn.2008.20096.
Dennis NA, Kim H, Cabeza R. Age-related differences in brain activity during true and false memory retrieval. Journal of cognitive neuroscience. 2008 Aug;20(8):1390–402.
Dennis, Nancy A., et al. “Age-related differences in brain activity during true and false memory retrieval.Journal of Cognitive Neuroscience, vol. 20, no. 8, Aug. 2008, pp. 1390–402. Epmc, doi:10.1162/jocn.2008.20096.
Dennis NA, Kim H, Cabeza R. Age-related differences in brain activity during true and false memory retrieval. Journal of cognitive neuroscience. 2008 Aug;20(8):1390–1402.
Journal cover image

Published In

Journal of cognitive neuroscience

DOI

EISSN

1530-8898

ISSN

0898-929X

Publication Date

August 2008

Volume

20

Issue

8

Start / End Page

1390 / 1402

Related Subject Headings

  • Recognition, Psychology
  • Reaction Time
  • Oxygen
  • Neuropsychological Tests
  • Middle Aged
  • Mental Recall
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans