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Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.

Publication ,  Journal Article
Mouraviev, V; Mayes, JM; Madden, JF; Sun, L; Polascik, TJ
Published in: Technol Cancer Res Treat
April 2007

In total, 1386 paraffin embedded radical prostatectomy specimens from patients with clinically localized prostate cancer (PCa) excised between 2002-06 were analyzed. Pathologic assessment paid particular attention to laterality and percentage of tumor involvement (PTI) along with pathologic Gleason Score (pGS). Completely unilateral cancers were identified in 254 (18.3%) patients, and in 39% cases of them the signs of clinically significant PCa were revealed. The majority of unilateral tumors (72%) were low volume with a PTI of < or =5. This study suggests that only a select group of men diagnosed with PCa have completely unilateral cancers that would be amenable to focal ablation therapy targeting 1 lobe. Further study is needed to develop predictive models for those patients likely to have small, unilateral cancers that may be amenable to focal therapy.

Duke Scholars

Published In

Technol Cancer Res Treat

DOI

ISSN

1533-0346

Publication Date

April 2007

Volume

6

Issue

2

Start / End Page

91 / 95

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Prostatectomy
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Male
  • Humans
  • Cryotherapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Mouraviev, V., Mayes, J. M., Madden, J. F., Sun, L., & Polascik, T. J. (2007). Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy. Technol Cancer Res Treat, 6(2), 91–95. https://doi.org/10.1177/153303460700600205
Mouraviev, Vladimir, Janice M. Mayes, John F. Madden, Leon Sun, and Thomas J. Polascik. “Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.Technol Cancer Res Treat 6, no. 2 (April 2007): 91–95. https://doi.org/10.1177/153303460700600205.
Mouraviev V, Mayes JM, Madden JF, Sun L, Polascik TJ. Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy. Technol Cancer Res Treat. 2007 Apr;6(2):91–5.
Mouraviev, Vladimir, et al. “Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.Technol Cancer Res Treat, vol. 6, no. 2, Apr. 2007, pp. 91–95. Pubmed, doi:10.1177/153303460700600205.
Mouraviev V, Mayes JM, Madden JF, Sun L, Polascik TJ. Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy. Technol Cancer Res Treat. 2007 Apr;6(2):91–95.
Journal cover image

Published In

Technol Cancer Res Treat

DOI

ISSN

1533-0346

Publication Date

April 2007

Volume

6

Issue

2

Start / End Page

91 / 95

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Prostatectomy
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Male
  • Humans
  • Cryotherapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis