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Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study.

Publication ,  Journal Article
Steinberg, KK; Pernarelli, JM; Marcus, M; Khoury, MJ; Schildkraut, JM; Marchbanks, PA
Published in: Genet Epidemiol
1998

Jewish women have been reported to have a higher risk for familial breast cancer than non-Jewish women and to be more likely to carry mutations in breast cancer genes such as BRCA1. Because BRCA1 mutations also increase women's risk for ovarian cancer, we asked whether Jewish women are at higher risk for familial ovarian cancer than non-Jewish women. To determine the effects of 1) Jewish religion and 2) ovarian cancer in a first-degree relative on women's risk for epithelial ovarian cancer, we used data from a population-based, case-control study conducted in 8 geographic regions in the United States from 1980 through 1982. The study group included 471 cases and 4,025 controls. Jewish women were more likely to have familial ovarian cancer than non-Jewish women [odds ratio (OR) = 8.4, 95% confidence interval (CI) = 2.6-28]. The risk of having ovarian cancer appeared to be greater in Jewish women having a first-degree relative with ovarian cancer (OR = 8.81, 95% CI = 2.02-38.23) than in non-Jewish women having a first-degree relative with ovarian cancer (OR = 3.01, 95% CI = 1.61-5.64), but differences between Jewish and non-Jewish women were not statistically significant. Jewish women with no first-degree relative with ovarian cancer had no increased risk for ovarian cancer (OR = 1.27, 95% CI = 0.74-2.91) compared to non-Jewish women. These results suggest that Jewish women may have a higher rate of familial ovarian cancer than non-Jewish women, but because the results are based on a small number of Jewish women with familial ovarian cancer, the results need to be confirmed in larger studies.

Duke Scholars

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

1998

Volume

15

Issue

1

Start / End Page

51 / 59

Location

United States

Related Subject Headings

  • United States
  • Risk Assessment
  • Ovarian Neoplasms
  • Middle Aged
  • Jews
  • Humans
  • Germ-Line Mutation
  • Genetics, Population
  • Female
  • Epidemiology
 

Citation

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Steinberg, K. K., Pernarelli, J. M., Marcus, M., Khoury, M. J., Schildkraut, J. M., & Marchbanks, P. A. (1998). Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study. Genet Epidemiol, 15(1), 51–59. https://doi.org/10.1002/(SICI)1098-2272(1998)15:1<51::AID-GEPI4>3.0.CO;2-7
Steinberg, K. K., J. M. Pernarelli, M. Marcus, M. J. Khoury, J. M. Schildkraut, and P. A. Marchbanks. “Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study.Genet Epidemiol 15, no. 1 (1998): 51–59. https://doi.org/10.1002/(SICI)1098-2272(1998)15:1<51::AID-GEPI4>3.0.CO;2-7.
Steinberg KK, Pernarelli JM, Marcus M, Khoury MJ, Schildkraut JM, Marchbanks PA. Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study. Genet Epidemiol. 1998;15(1):51–9.
Steinberg, K. K., et al. “Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study.Genet Epidemiol, vol. 15, no. 1, 1998, pp. 51–59. Pubmed, doi:10.1002/(SICI)1098-2272(1998)15:1<51::AID-GEPI4>3.0.CO;2-7.
Steinberg KK, Pernarelli JM, Marcus M, Khoury MJ, Schildkraut JM, Marchbanks PA. Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study. Genet Epidemiol. 1998;15(1):51–59.
Journal cover image

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

1998

Volume

15

Issue

1

Start / End Page

51 / 59

Location

United States

Related Subject Headings

  • United States
  • Risk Assessment
  • Ovarian Neoplasms
  • Middle Aged
  • Jews
  • Humans
  • Germ-Line Mutation
  • Genetics, Population
  • Female
  • Epidemiology