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Clinical findings for residents near a polyurethane foam manufacturing plant.

Publication ,  Journal Article
Darcey, D; Lipscomb, HJ; Epling, C; Pate, W; Cherry, LP; Bernstein, J
Published in: Arch Environ Health
2002

Clinical findings for 38 community residents who complained of symptoms they attributed to exposure to air emissions from nearby fiber processing and polyurethane foam manufacturing facilities are reported. Common complaints included headache, mucosal irritation, shortness of breath, chest tightness, and wheezing. Airway hyperreactivity, measured by methacholine challenge, was observed in 8 individuals (22% of those tested), who also reported temporal relationships between exposure to visible emissions or odors and symptoms consistent with environmentally induced asthma. Six individuals (18.2%) had antibodies to at least 1 of the 3 common industrial diisocyanates. The number of individuals with antibodies to diisocyanates, coupled with the absence of other diisocyanate exposure, was highly suggestive of environmental exposure. The findings raised concern that some residents may have become sensitized to toluene diisocyanate.

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Published In

Arch Environ Health

DOI

ISSN

0003-9896

Publication Date

2002

Volume

57

Issue

3

Start / End Page

239 / 246

Location

United States

Related Subject Headings

  • Toxicology
  • Toluene 2,4-Diisocyanate
  • Surveys and Questionnaires
  • Respiratory Hypersensitivity
  • Respiratory Function Tests
  • Polyurethanes
  • North Carolina
  • Middle Aged
  • Male
  • Industry
 

Citation

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Darcey, D., Lipscomb, H. J., Epling, C., Pate, W., Cherry, L. P., & Bernstein, J. (2002). Clinical findings for residents near a polyurethane foam manufacturing plant. Arch Environ Health, 57(3), 239–246. https://doi.org/10.1080/00039890209602943
Darcey, Dennis, Hester J. Lipscomb, Carol Epling, William Pate, Lorene P. Cherry, and Jonathan Bernstein. “Clinical findings for residents near a polyurethane foam manufacturing plant.Arch Environ Health 57, no. 3 (2002): 239–46. https://doi.org/10.1080/00039890209602943.
Darcey D, Lipscomb HJ, Epling C, Pate W, Cherry LP, Bernstein J. Clinical findings for residents near a polyurethane foam manufacturing plant. Arch Environ Health. 2002;57(3):239–46.
Darcey, Dennis, et al. “Clinical findings for residents near a polyurethane foam manufacturing plant.Arch Environ Health, vol. 57, no. 3, 2002, pp. 239–46. Pubmed, doi:10.1080/00039890209602943.
Darcey D, Lipscomb HJ, Epling C, Pate W, Cherry LP, Bernstein J. Clinical findings for residents near a polyurethane foam manufacturing plant. Arch Environ Health. 2002;57(3):239–246.

Published In

Arch Environ Health

DOI

ISSN

0003-9896

Publication Date

2002

Volume

57

Issue

3

Start / End Page

239 / 246

Location

United States

Related Subject Headings

  • Toxicology
  • Toluene 2,4-Diisocyanate
  • Surveys and Questionnaires
  • Respiratory Hypersensitivity
  • Respiratory Function Tests
  • Polyurethanes
  • North Carolina
  • Middle Aged
  • Male
  • Industry