Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.
Publication
, Journal Article
Akke, M; Liu, J; Cavanagh, J; Erickson, HP; Palmer, AG
Published in: Nat Struct Biol
January 1998
A novel off-resonance rotating-frame 15N NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 microseconds in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the beta-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the beta-sheets. Flexibility of the loop containing the Arg-Gly-Asp (RGD) tripeptide may affect the accessibility of this motif in protein-protein interactions.
Duke Scholars
Published In
Nat Struct Biol
DOI
ISSN
1072-8368
Publication Date
January 1998
Volume
5
Issue
1
Start / End Page
55 / 59
Location
United States
Related Subject Headings
- Tenascin
- Protein Structure, Tertiary
- Protein Denaturation
- Protein Conformation
- Protein Binding
- Nuclear Magnetic Resonance, Biomolecular
- Motion
- Hydrogen Bonding
- Humans
- Fibronectins
Citation
APA
Chicago
ICMJE
MLA
NLM
Akke, M., Liu, J., Cavanagh, J., Erickson, H. P., & Palmer, A. G. (1998). Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. Nat Struct Biol, 5(1), 55–59. https://doi.org/10.1038/nsb0198-55
Akke, M., J. Liu, J. Cavanagh, H. P. Erickson, and A. G. Palmer. “Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.” Nat Struct Biol 5, no. 1 (January 1998): 55–59. https://doi.org/10.1038/nsb0198-55.
Akke M, Liu J, Cavanagh J, Erickson HP, Palmer AG. Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. Nat Struct Biol. 1998 Jan;5(1):55–9.
Akke, M., et al. “Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.” Nat Struct Biol, vol. 5, no. 1, Jan. 1998, pp. 55–59. Pubmed, doi:10.1038/nsb0198-55.
Akke M, Liu J, Cavanagh J, Erickson HP, Palmer AG. Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. Nat Struct Biol. 1998 Jan;5(1):55–59.
Published In
Nat Struct Biol
DOI
ISSN
1072-8368
Publication Date
January 1998
Volume
5
Issue
1
Start / End Page
55 / 59
Location
United States
Related Subject Headings
- Tenascin
- Protein Structure, Tertiary
- Protein Denaturation
- Protein Conformation
- Protein Binding
- Nuclear Magnetic Resonance, Biomolecular
- Motion
- Hydrogen Bonding
- Humans
- Fibronectins