Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.
Publication
, Journal Article
Gottwein, E; Cullen, BR
Published in: Cell host & microbe
June 2008
MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and cellular origin can positively or negatively influence viral replication. Viral miRNAs can directly alter host physiology, including components of the immune system, and host miRNAs can directly alter the virus life cycle. Here, we discuss what is known about how viral and cellular miRNAs influence viral replication and pathogenic potential through their regulation of viral mRNAs or by reshaping cellular gene expression.
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Published In
Cell host & microbe
DOI
EISSN
1934-6069
ISSN
1931-3128
Publication Date
June 2008
Volume
3
Issue
6
Start / End Page
375 / 387
Related Subject Headings
- Viruses
- Virus Physiological Phenomena
- Virus Diseases
- Sequence Alignment
- RNA, Viral
- MicroRNAs
- Immunology
- Humans
- Host-Pathogen Interactions
- Gene Expression Regulation, Viral
Citation
APA
Chicago
ICMJE
MLA
NLM
Gottwein, E., & Cullen, B. R. (2008). Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host & Microbe, 3(6), 375–387. https://doi.org/10.1016/j.chom.2008.05.002
Gottwein, Eva, and Bryan R. Cullen. “Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.” Cell Host & Microbe 3, no. 6 (June 2008): 375–87. https://doi.org/10.1016/j.chom.2008.05.002.
Gottwein E, Cullen BR. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell host & microbe. 2008 Jun;3(6):375–87.
Gottwein, Eva, and Bryan R. Cullen. “Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.” Cell Host & Microbe, vol. 3, no. 6, June 2008, pp. 375–87. Epmc, doi:10.1016/j.chom.2008.05.002.
Gottwein E, Cullen BR. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell host & microbe. 2008 Jun;3(6):375–387.
Published In
Cell host & microbe
DOI
EISSN
1934-6069
ISSN
1931-3128
Publication Date
June 2008
Volume
3
Issue
6
Start / End Page
375 / 387
Related Subject Headings
- Viruses
- Virus Physiological Phenomena
- Virus Diseases
- Sequence Alignment
- RNA, Viral
- MicroRNAs
- Immunology
- Humans
- Host-Pathogen Interactions
- Gene Expression Regulation, Viral