Bacterial outer membrane vesicles and the host-pathogen interaction.
Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.
Duke Scholars
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- Humans
- Gram-Negative Bacterial Infections
- Gram-Negative Bacteria
- Developmental Biology
- Cell Wall
- Animals
- 52 Psychology
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 17 Psychology and Cognitive Sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Humans
- Gram-Negative Bacterial Infections
- Gram-Negative Bacteria
- Developmental Biology
- Cell Wall
- Animals
- 52 Psychology
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 17 Psychology and Cognitive Sciences