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Gold nanocages: Engineering their structure for biomedical applications

Publication ,  Journal Article
Chen, J; Wiley, B; Li, ZY; Campbell, D; Saeki, F; Cang, H; Au, L; Lee, J; Li, X; Xia, Y
Published in: Advanced Materials
September 16, 2005

The galvanic replacement reaction between a Ag template and HAuCl 4 in an aqueous solution transforms 30-200 nm Ag nanocubes into Au nanoboxes and nanocages (nanoboxes with porous walls). By controlling the molar ratio of Ag to HAuCl4, the extinction peak of resultant structures can be continuously tuned from the blue (400 nm) to the near-infrared (1200 nm) region of the electromagnetic spectrum. These hollow Au nanostructures are characterized by extraordinarily large cross-sections for both absorption and scattering. Optical coherence tomography measurements indicate that the 36 nm nanocage has a scattering cross-section of ∼ 0.8 × 10-15 m2 and an absorption cross-section of ∼ 7.3 × 10 -15 m2. The absorption cross-section is more than five orders of magnitude larger than those of conventional organic dyes. Exposure of Au nanocages to a camera flash resulted in the melting and conversion of Au nanocages into spherical particles due to photothermal heating. Discrete-dipole-approximation calculations suggest that the magnitudes of both scattering and absorption cross-sections of Au nanocages can be tailored by controlling their dimensions, as well as the thickness and porosity of their walls. This novel class of hollow nanostructures is expected to find use as both a contrast agent for optical imaging in early stage tumor detection and as a therapeutic agent for photothermal cancer treatment. © 2005 WILEY-VCH Verlag GmbH S. Co. KGaA, Weinheim.

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Published In

Advanced Materials

DOI

ISSN

0935-9648

Publication Date

September 16, 2005

Volume

17

Issue

18

Start / End Page

2255 / 2261

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

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Chen, J., Wiley, B., Li, Z. Y., Campbell, D., Saeki, F., Cang, H., … Xia, Y. (2005). Gold nanocages: Engineering their structure for biomedical applications. Advanced Materials, 17(18), 2255–2261. https://doi.org/10.1002/adma.200500833
Chen, J., B. Wiley, Z. Y. Li, D. Campbell, F. Saeki, H. Cang, L. Au, J. Lee, X. Li, and Y. Xia. “Gold nanocages: Engineering their structure for biomedical applications.” Advanced Materials 17, no. 18 (September 16, 2005): 2255–61. https://doi.org/10.1002/adma.200500833.
Chen J, Wiley B, Li ZY, Campbell D, Saeki F, Cang H, et al. Gold nanocages: Engineering their structure for biomedical applications. Advanced Materials. 2005 Sep 16;17(18):2255–61.
Chen, J., et al. “Gold nanocages: Engineering their structure for biomedical applications.” Advanced Materials, vol. 17, no. 18, Sept. 2005, pp. 2255–61. Scopus, doi:10.1002/adma.200500833.
Chen J, Wiley B, Li ZY, Campbell D, Saeki F, Cang H, Au L, Lee J, Li X, Xia Y. Gold nanocages: Engineering their structure for biomedical applications. Advanced Materials. 2005 Sep 16;17(18):2255–2261.
Journal cover image

Published In

Advanced Materials

DOI

ISSN

0935-9648

Publication Date

September 16, 2005

Volume

17

Issue

18

Start / End Page

2255 / 2261

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences