Skip to main content

Circulating levels of inflammatory cytokines and risk of colorectal adenomas.

Publication ,  Journal Article
Kim, S; Keku, TO; Martin, C; Galanko, J; Woosley, JT; Schroeder, JC; Satia, JA; Halabi, S; Sandler, RS
Published in: Cancer Res
January 1, 2008

The association between obesity and colorectal neoplasia may be mediated by inflammation. Circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) are elevated in the obese. Adipose tissue can produce and release the inflammatory cytokines that are potentially procarcinogenic. We examined circulating levels of CRP, IL-6, and TNF-alpha in relation to risk factors and the prevalence of colorectal adenomas. Plasma levels of CRP, IL-6, and TNF-alpha were quantified in 873 participants (242 colorectal adenoma cases and 631 controls) in a colonoscopy-based cross-sectional study conducted between 1998 and 2002. Multivariable logistic regression was used to estimate associations between known risk factors for colorectal neoplasia and circulating levels of inflammatory cytokines and associations between inflammatory cytokines and colorectal adenomas. Several known risk factors for colorectal neoplasia were associated with higher levels of inflammatory cytokines, including older age, current smoking, and increasing adiposity. The prevalence of colorectal adenomas was associated with higher concentrations of IL-6 and TNF-alpha and, to a lesser degree, with CRP. For IL-6, adjusted odds ratios (OR) for colorectal adenomas were 1.79 [95% confidence interval (CI), 1.19-2.69] for the second highest plasma level and 1.85 (95% CI, 1.24-2.75) for the highest level compared with the reference level. A similar association was found with TNF-alpha, with adjusted ORs of 1.56 (95% CI, 1.03-2.36) and 1.66 (95% CI, 1.10-2.52), respectively. Our findings indicate that systemic inflammation might be involved in the early development of colorectal neoplasia.

Duke Scholars

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

January 1, 2008

Volume

68

Issue

1

Start / End Page

323 / 328

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Risk
  • Prevalence
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Interleukin-6
  • Inflammation
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, S., Keku, T. O., Martin, C., Galanko, J., Woosley, J. T., Schroeder, J. C., … Sandler, R. S. (2008). Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res, 68(1), 323–328. https://doi.org/10.1158/0008-5472.CAN-07-2924
Kim, Sangmi, Temitope O. Keku, Christopher Martin, Joseph Galanko, John T. Woosley, Jane C. Schroeder, Jessie A. Satia, Susan Halabi, and Robert S. Sandler. “Circulating levels of inflammatory cytokines and risk of colorectal adenomas.Cancer Res 68, no. 1 (January 1, 2008): 323–28. https://doi.org/10.1158/0008-5472.CAN-07-2924.
Kim S, Keku TO, Martin C, Galanko J, Woosley JT, Schroeder JC, et al. Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res. 2008 Jan 1;68(1):323–8.
Kim, Sangmi, et al. “Circulating levels of inflammatory cytokines and risk of colorectal adenomas.Cancer Res, vol. 68, no. 1, Jan. 2008, pp. 323–28. Pubmed, doi:10.1158/0008-5472.CAN-07-2924.
Kim S, Keku TO, Martin C, Galanko J, Woosley JT, Schroeder JC, Satia JA, Halabi S, Sandler RS. Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res. 2008 Jan 1;68(1):323–328.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

January 1, 2008

Volume

68

Issue

1

Start / End Page

323 / 328

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Risk
  • Prevalence
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Interleukin-6
  • Inflammation
  • Humans
  • Female