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Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart.

Publication ,  Journal Article
Goddeeris, MM; Rho, S; Petiet, A; Davenport, CL; Johnson, GA; Meyers, EN; Klingensmith, J
Published in: Development
May 2008

Septation of the mammalian heart into four chambers requires the orchestration of multiple tissue progenitors. Abnormalities in this process can result in potentially fatal atrioventricular septation defects (AVSD). The contribution of extracardiac cells to atrial septation has recently been recognized. Here, we use a genetic marker and novel magnetic resonance microscopy techniques to demonstrate the origins of the dorsal mesenchymal protrusion in the dorsal mesocardium, and its substantial contribution to atrioventricular septation. We explore the functional significance of this tissue to atrioventricular septation through study of the previously uncharacterized AVSD phenotype of Shh(-/-) mutant mouse embryos. We demonstrate that Shh signaling is required within the dorsal mesocardium for its contribution to the atria. Failure of this addition results in severe AVSD. These studies demonstrate that AVSD can result from a primary defect in dorsal mesocardium, providing a new paradigm for the understanding of human AVSD.

Duke Scholars

Published In

Development

DOI

ISSN

0950-1991

Publication Date

May 2008

Volume

135

Issue

10

Start / End Page

1887 / 1895

Location

England

Related Subject Headings

  • Signal Transduction
  • Mutation
  • Mice, Mutant Strains
  • Mice
  • Mesoderm
  • Hedgehog Proteins
  • Heart Septal Defects, Ventricular
  • Heart Atria
  • Fetal Heart
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Goddeeris, M. M., Rho, S., Petiet, A., Davenport, C. L., Johnson, G. A., Meyers, E. N., & Klingensmith, J. (2008). Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. Development, 135(10), 1887–1895. https://doi.org/10.1242/dev.016147
Goddeeris, Matthew M., Silvia Rho, Alexandra Petiet, Chandra L. Davenport, G Allan Johnson, Erik N. Meyers, and John Klingensmith. “Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart.Development 135, no. 10 (May 2008): 1887–95. https://doi.org/10.1242/dev.016147.
Goddeeris MM, Rho S, Petiet A, Davenport CL, Johnson GA, Meyers EN, et al. Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. Development. 2008 May;135(10):1887–95.
Goddeeris, Matthew M., et al. “Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart.Development, vol. 135, no. 10, May 2008, pp. 1887–95. Pubmed, doi:10.1242/dev.016147.
Goddeeris MM, Rho S, Petiet A, Davenport CL, Johnson GA, Meyers EN, Klingensmith J. Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. Development. 2008 May;135(10):1887–1895.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

May 2008

Volume

135

Issue

10

Start / End Page

1887 / 1895

Location

England

Related Subject Headings

  • Signal Transduction
  • Mutation
  • Mice, Mutant Strains
  • Mice
  • Mesoderm
  • Hedgehog Proteins
  • Heart Septal Defects, Ventricular
  • Heart Atria
  • Fetal Heart
  • Animals