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ApoE isoform affects LTP in human targeted replacement mice.

Publication ,  Journal Article
Trommer, BL; Shah, C; Yun, SH; Gamkrelidze, G; Pasternak, ES; Ye, GL; Sotak, M; Sullivan, PM; Pasternak, JF; LaDu, MJ
Published in: Neuroreport
December 3, 2004

Inheritance of the epsilon4 allele for apolipoprotein E (apoE) increases the risk of Alzheimer disease and memory impairment, whereas epsilon2 decreases these risks compared with the most common epsilon3 allele, but the mechanism for these effects is unknown. Long-term potentiation (LTP) is an experimentally induced increase in synaptic efficacy that models memory. Using hippocampal slices from wild type (WT), apoE knockout (apoE-KO), and targeted replacement mice expressing human apoE2, E3, or E4 (apoE-TR) we found that although all strains had comparable basal synaptic transmission, LTP was significantly greater in WT and apoE3-TR than in apoE-KO, apoE2-TR or apoE4-TR. This novel system may be used to investigate the mechanisms of apoE isoform dependent modulation of susceptibility to memory impairment.

Duke Scholars

Published In

Neuroreport

DOI

ISSN

0959-4965

Publication Date

December 3, 2004

Volume

15

Issue

17

Start / End Page

2655 / 2658

Location

England

Related Subject Headings

  • Protein Isoforms
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Long-Term Potentiation
  • In Vitro Techniques
  • Humans
  • Hippocampus
  • Electric Stimulation
 

Citation

APA
Chicago
ICMJE
MLA
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Trommer, B. L., Shah, C., Yun, S. H., Gamkrelidze, G., Pasternak, E. S., Ye, G. L., … LaDu, M. J. (2004). ApoE isoform affects LTP in human targeted replacement mice. Neuroreport, 15(17), 2655–2658. https://doi.org/10.1097/00001756-200412030-00020
Trommer, Barbara L., Chirag Shah, Sung Hwan Yun, Georgi Gamkrelidze, Emily S. Pasternak, Gui Lan Ye, Michelle Sotak, Patrick M. Sullivan, Joseph F. Pasternak, and Mary Jo LaDu. “ApoE isoform affects LTP in human targeted replacement mice.Neuroreport 15, no. 17 (December 3, 2004): 2655–58. https://doi.org/10.1097/00001756-200412030-00020.
Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Ye GL, et al. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport. 2004 Dec 3;15(17):2655–8.
Trommer, Barbara L., et al. “ApoE isoform affects LTP in human targeted replacement mice.Neuroreport, vol. 15, no. 17, Dec. 2004, pp. 2655–58. Pubmed, doi:10.1097/00001756-200412030-00020.
Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Ye GL, Sotak M, Sullivan PM, Pasternak JF, LaDu MJ. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport. 2004 Dec 3;15(17):2655–2658.

Published In

Neuroreport

DOI

ISSN

0959-4965

Publication Date

December 3, 2004

Volume

15

Issue

17

Start / End Page

2655 / 2658

Location

England

Related Subject Headings

  • Protein Isoforms
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Long-Term Potentiation
  • In Vitro Techniques
  • Humans
  • Hippocampus
  • Electric Stimulation