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Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.

Publication ,  Journal Article
Reid, GG; Edwards, JG; Marshall, GE; Sutcliffe, RG; Lee, WR
Published in: Exp Cell Res
October 10, 1997

Using scanning electron microscopy and fluorescence microscopy, we have found that apical microvilli of diverse cell types, including nonepithelial cells, elongate in culture in response to the oxidative stress of hydrogen peroxide. The microvilli induced in culture on retinal pigment epithelial cells display a 30-nm axial periodicity similar to that described for stable microvilli of intestinal brush border. Microvilli can also be induced to elongate by chelating intracellular Ca2+ and by the Ca(2+)-uptake inhibitor thapsigargin. Thus a response of microvillar protrusion occurs widely and may be related to depletion of intracellular calcium stores.

Duke Scholars

Published In

Exp Cell Res

DOI

ISSN

0014-4827

Publication Date

October 10, 1997

Volume

236

Issue

1

Start / End Page

86 / 93

Location

United States

Related Subject Headings

  • Xanthine Oxidase
  • Signal Transduction
  • Pigment Epithelium of Eye
  • Organelles
  • Microvilli
  • Microscopy, Electron, Scanning
  • Microscopy, Electron
  • Ionophores
  • Indicators and Reagents
  • Hydrogen Peroxide
 

Citation

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Reid, G. G., Edwards, J. G., Marshall, G. E., Sutcliffe, R. G., & Lee, W. R. (1997). Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium. Exp Cell Res, 236(1), 86–93. https://doi.org/10.1006/excr.1997.3701
Reid, G. G., J. G. Edwards, G. E. Marshall, R. G. Sutcliffe, and W. R. Lee. “Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.Exp Cell Res 236, no. 1 (October 10, 1997): 86–93. https://doi.org/10.1006/excr.1997.3701.
Reid GG, Edwards JG, Marshall GE, Sutcliffe RG, Lee WR. Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium. Exp Cell Res. 1997 Oct 10;236(1):86–93.
Reid, G. G., et al. “Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.Exp Cell Res, vol. 236, no. 1, Oct. 1997, pp. 86–93. Pubmed, doi:10.1006/excr.1997.3701.
Reid GG, Edwards JG, Marshall GE, Sutcliffe RG, Lee WR. Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium. Exp Cell Res. 1997 Oct 10;236(1):86–93.
Journal cover image

Published In

Exp Cell Res

DOI

ISSN

0014-4827

Publication Date

October 10, 1997

Volume

236

Issue

1

Start / End Page

86 / 93

Location

United States

Related Subject Headings

  • Xanthine Oxidase
  • Signal Transduction
  • Pigment Epithelium of Eye
  • Organelles
  • Microvilli
  • Microscopy, Electron, Scanning
  • Microscopy, Electron
  • Ionophores
  • Indicators and Reagents
  • Hydrogen Peroxide