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Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas.

Publication ,  Journal Article
Cochran, AJ; Holland, GN; Wen, DR; Herschman, HR; Lee, WR; Foos, RY; Straatsma, BR
Published in: Investigative ophthalmology & visual science
August 1983

The authors sought S-100 protein in sections cut from formalin- or glutaraldehyde-fixed, paraffin-embedded tumors from the eye and other sites by an immunoperoxidase technique, using rabbit antibovine S-100 protein antiserum, swine antirabbit serum, a peroxidase-antiperoxidase preparation, and amino-ethylcarbizole as developer. Tissue from 26 intraocular tumors was examined, the pathologic diagnosis being unknown to the investigators at that time that the tests were performed. Thirteen of 16 malignant melanomas of the choroid contained S-100 protein (81%), while only one of seven retinoblastomas contained S-100 protein (14%). One cutaneous malignant melanoma metastatic to the eye contained S-100 protein, while none of three metastatic nonmelanocytic, nonneural tumors contained the protein. These results are similar to our findings with nonocular tumors, in which 56 of 56 cutaneous melanomas contained S-100 protein (100%) and only 1 of 51 nonneural, nonmelanocytic tumors contained S-100 protein (2%). S-100 protein may be useful as a marker for ocular malignant melanoma.

Published In

Investigative ophthalmology & visual science

ISSN

0146-0404

Publication Date

August 1983

Volume

24

Issue

8

Start / End Page

1153 / 1155

Location

united states

Related Subject Headings

  • S100 Proteins
  • Retinoblastoma
  • Ophthalmology & Optometry
  • Nerve Tissue Proteins
  • Melanoma
  • Humans
  • Eye Neoplasms
  • 3212 Ophthalmology and optometry
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cochran, A. J., Holland, G. N., Wen, D. R., Herschman, H. R., Lee, W. R., Foos, R. Y., & Straatsma, B. R. (1983). Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas. Investigative Ophthalmology & Visual Science, 24(8), 1153–1155.
Cochran, A. J., G. N. Holland, D. R. Wen, H. R. Herschman, W. R. Lee, R. Y. Foos, and B. R. Straatsma. “Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas.Investigative Ophthalmology & Visual Science 24, no. 8 (August 1983): 1153–55.
Cochran AJ, Holland GN, Wen DR, Herschman HR, Lee WR, Foos RY, et al. Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas. Investigative ophthalmology & visual science. 1983 Aug;24(8):1153–5.
Cochran, A. J., et al. “Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas.Investigative Ophthalmology & Visual Science, vol. 24, no. 8, Aug. 1983, pp. 1153–55.
Cochran AJ, Holland GN, Wen DR, Herschman HR, Lee WR, Foos RY, Straatsma BR. Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas. Investigative ophthalmology & visual science. 1983 Aug;24(8):1153–1155.

Published In

Investigative ophthalmology & visual science

ISSN

0146-0404

Publication Date

August 1983

Volume

24

Issue

8

Start / End Page

1153 / 1155

Location

united states

Related Subject Headings

  • S100 Proteins
  • Retinoblastoma
  • Ophthalmology & Optometry
  • Nerve Tissue Proteins
  • Melanoma
  • Humans
  • Eye Neoplasms
  • 3212 Ophthalmology and optometry
  • 11 Medical and Health Sciences
  • 06 Biological Sciences