Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.
Publication
, Journal Article
Syu, WJ; Lee, WR; Du, B; Yu, QC; Essex, M; Lee, TH
Published in: J Virol
November 1991
All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp41 as a working model, the functional significance of these highly conserved cysteines was investigated. We report here that substituting the two conserved cysteine residues in this domain of gp41 with glycine residues resulted in the loss of viral infectivity, which could be attributed to severe impairment in the processing of gp160 precursor to gp120.
Duke Scholars
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
November 1991
Volume
65
Issue
11
Start / End Page
6349 / 6352
Location
United States
Related Subject Headings
- Virology
- Transfection
- RNA-Directed DNA Polymerase
- Proviruses
- Protein Precursors
- Oligodeoxyribonucleotides
- Mutagenesis, Site-Directed
- Molecular Sequence Data
- HIV-1
- HIV Reverse Transcriptase
Citation
APA
Chicago
ICMJE
MLA
NLM
Syu, W. J., Lee, W. R., Du, B., Yu, Q. C., Essex, M., & Lee, T. H. (1991). Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. J Virol, 65(11), 6349–6352. https://doi.org/10.1128/JVI.65.11.6349-6352.1991
Syu, W. J., W. R. Lee, B. Du, Q. C. Yu, M. Essex, and T. H. Lee. “Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.” J Virol 65, no. 11 (November 1991): 6349–52. https://doi.org/10.1128/JVI.65.11.6349-6352.1991.
Syu WJ, Lee WR, Du B, Yu QC, Essex M, Lee TH. Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. J Virol. 1991 Nov;65(11):6349–52.
Syu, W. J., et al. “Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.” J Virol, vol. 65, no. 11, Nov. 1991, pp. 6349–52. Pubmed, doi:10.1128/JVI.65.11.6349-6352.1991.
Syu WJ, Lee WR, Du B, Yu QC, Essex M, Lee TH. Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. J Virol. 1991 Nov;65(11):6349–6352.
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
November 1991
Volume
65
Issue
11
Start / End Page
6349 / 6352
Location
United States
Related Subject Headings
- Virology
- Transfection
- RNA-Directed DNA Polymerase
- Proviruses
- Protein Precursors
- Oligodeoxyribonucleotides
- Mutagenesis, Site-Directed
- Molecular Sequence Data
- HIV-1
- HIV Reverse Transcriptase